NEHAL MOHSEN AHMED ELSHERBINY

Nehal Elsherbiny • Associate professor of Biochemistry • Scopus profile https://wwwscopuscom/authid/detailuri?authorId=55441041500 • Publon profile https://publonscom/researcher/3254210/nehal-elsherbiny/ • More than 100 Publications • Reviewer for more than 100 Scopus/ISI journals • Associate editor for Frontiers in Endocrinology Journal • Special issue lead guest editor for the Journal of Diabetes Research and Frontiers in Endocrinology Journal • Listed in Top 2% of Scientists Worldwide identified by Stanford University

Resume

Study Schedule

Research And Literature

Research Projects

Awards

Day	Course	Time
الأحد	---	15:00 - 17:00

Elsherbiny NM, Abd El Galil KH, Gabr MM, Al-Gayyar MM, Eissa LA, El-Shishtawy MM (2012) Reno-protective effect of NECA in diabetic nephropathy: implication of IL-18 and ICAM-1 Eur Cytokine Netw, 23(3): 78-86
Al-Gayyar MM, Elsherbiny NM (2013) Contribution of TNF-α to the development of retinal neurodegenerative disorders Eur Cytokine Netw, 24(1): 27-36
Elsherbiny NM, Ahmad S, Naime M, Elsherbini AM, Fulzele S, Al-Gayyar MM, Eissa LA, El-Shishtawy MM, Liou GI (2013) ABT-702, an adenosine kinase inhibitor, attenuates inflammation in diabetic retinopathy Life Sci, 93 (2-3): 78-88
Elsherbiny NM, Naime M, Ahmad S, Elsherbini AM, Mohammad S, Fulzele S, El-Remessy AB, Al-Gayyar MM, Eissa LA, El-Shishtawy MM, Han G, White R, Haroldo TF, Liou GI (2013) Potential roles of adenosine deaminase-2 in diabetic retinopathy Biochem Biophys Res Commun, 436(3): 355-61
Elsherbiny NM, Al-Gayyar MM (2013) Adenosine Receptors: New Therapeutic Targets for Inflammation in Diabetic Nephropathy Inflamm Allergy Drug Targets, 12(3):153-61
Ahmad S, Fatteh N, El-Sherbiny NM, Naime M, Ibrahim AS, El-Sherbini AM, El-Shafey SA, Khan S, Fulzele S, Gonzales J, Liou GI (2013) Potential role of A2A adenosine receptor in traumatic optic neuropathy J Neuroimmunol, 264(1-2):54-64
Bayomi HS, Elsherbiny NM, El-Gayar AM, Al-Gayyar MM (2013) Evaluation of renal protective effects of inhibiting TGF-β type I receptor in a cisplatin-induced nephrotoxicity model Eur Cytokine Netw 24(4):139-47
Ahmad S, Fatteh N, El-Sherbiny NM, Naime M, Ibrahim AS, El-Sherbini AM, El-Shafey SA, Khan S, Fulzele S, Gonzales J, Liou GI (2013) Potential role of A2A adenosine receptor in traumatic optic neuropathy J Neuroimmunol, 264(1-2):54-64
Bayomi HS, Elsherbiny NM, El-Gayar AM, Al-Gayyar MM (2013) Evaluation of renal protective effects of inhibiting TGF-β type I receptor in a cisplatin-induced nephrotoxicity model Eur Cytokine Netw 24(4):139-47
Pye C, Elsherbiny NM, Ibrahim AS, Liou GI, Chadli A, Elmarakby AA (2014) Adenosine Kinase Inhibition Protects The Kidney Against Streptozotocin-Induced Diabetes Through Anti-inflammatory and Anti-oxidant Mechanisms Pharmacological research, Pharmacol Res 85:45-54
Ahmad S, Elsherbiny NM, Haque R, Khan MB, Ishrat T, Shah ZA, Khan MM, Ali M, Jamal A, Katare DP, Liou GI, Bhatia K (2014) Sesamin attenuates neurotoxicity in mouse model of ischemic brain stroke Neurotoxicology, 45:100-10
Ahmad S, El-Sherbiny NM, Bhatia k, El-Sherbini A, Fulzele S, Liou GI (2014) Inhibition of adenosine kinase attenuates inflammation and neurotoxicity in traumatic optic neuropathy J of Neuroimmunology, 277(1-2):96-104
El Kramani N, Elsherbiny NM, El-Gayar AM, Ebrahim MA, Al-Gayyar MM (2015) Tumor Necrosis Factor Receptor 2: Its Clinical Significance and Clinicopathologic Correlation in acute leukemias Journal of Applied Pharmaceutical Science, 5 (11): 79-83
El Kramani N, Elsherbiny NM, El-Gayar AM, Ebrahim MA, Al-Gayyar MM (2015) Evaluation of Leukocytes Tumor Necrosis Factor Receptor 2 in Acute Leukemia Patients Clinical Research and Development, 2 (2): 155-120
Eissa LA, Elsherbiny NM, Magmomah AO (2015) Propolis restored adiponectin level in type 2 diabetes through PPARγ activation Egyptian Journal of Basic and Applied Sciences, 2 (4): 318–326
Elsherbiny NM, El-Sherbiny M, Said E (2015) Amelioration of experimentally induced diabetic nephropathy and renal damage by nilotinib J Physiol Biochem 71(4): 635-48
Eisa NH, ElSherbiny NM, Shebl AM, Eissa LA, El-Shishtawy MM (2015) Phenethyl isothiocyanate potentiates anti-tumour effect of doxorubicin through Akt-dependent pathway Cell Biochem Funct 33(8): 541-51
Elsherbiny NM, Al-Gayyar MM, Abd El Galil KH (2015) Nephroprotective role of dipyridamole in diabetic nephropathy: Effect on inflammation and apoptosis Life Sci 143:8-17
Elsherbiny NM, Eladl MA, Al-Gayyar MM (2016) Renal protective effects of arjunolic acid in a cisplatin-induced nephrotoxicity model Cytokine 77:26-34
Elsherbiny NM, Al-Gayyar MM (2016) The role of IL-18 in type 1 diabetic nephropathy: The problem and future treatment Cytokine 81:15-22
Ibrahim AS, Mander S, Hussein KA, Elsherbiny NM, Smith SB, Al-Shabrawey M, Tawfik A (2016) Hyperhomocysteinemia disrupts retinal pigment epithelial structure and function with features of age-related macular degeneration Oncotarget 7(8):8532-45
Elsherbiny NM, Salama MF, Said E, El-Sherbiny M, Al-Gayyar MM (2016) Crocin protects against doxorubicin-induced myocardial toxicity in rats through down-regulation of inflammatory and apoptic pathways Chem Biol Interact 247:39-48
Alsheblak M, Elsherbiny NM, El-Karef A, El-Shishtawy M (2016) Protective effects of L-carnosine on CCl4 –induced hepatic injury in rats Eur Cytokine Netw 27(1): 6-15
Ahmad S, Elsherbiny NM, Jamal MS, Al-Zahrani FA, Haque R, Khan R, Zaidi SK, Al-Qahtani MH, Liou GI, Bhatia K (2016) Anti-inflammatory role of sesamin in STZ induced mice model of diabetic retinopathy Journal of Neuroimmunology 295-296:47-53
Samra YA, Said HS, Elsherbiny NM, Liou GI, El-Shishtawy MM, Eissa LA (2016) Cepharanthine and Piperine ameliorate diabetic nephropathy in rats: role of NF-κB and NLRP3 inflammasome Life Sci 157:187-99
Elsherbiny NM, Al-Gayyar MM (2016) Anti-tumor activity of arjunolic acid against Ehrlich Ascites Carcinoma cells in vivo and in vitro through blocking TGF-β type 1 receptor Biomed Pharmacother 82:28-34
Elsherbiny NM, Younis NN, Shaheen MA, Elseweidy MM (2016) The synergistic effect between vanillin and doxorubicin in ehrlich ascites carcinoma solid tumor and MCF-7 human breast cancer cell line Pathol Res Pract 212(9):767-77
Arffa ML, Zapf MA, Kothari AN, Chang V, Gupta GN, Ding X, Al-Gayyar MM, Syn W, Elsherbiny NM, Kuo PC, Mi Z (2016) Epigallocatechin-3-Gallate Upregulates miR-221 to Inhibit Osteopontin-Dependent Hepatic Fibrosis PLoS One 11(12):e0167435
Elfar GA, Ebrahim ME, Elsherbiny NM, Eissa LA (2016) Validity of osteoprotegerin and receptor activator of NF-κB ligand for detection of bone metastasis in breast cancer Oncol Res 25(4):641-650
Eissa LA, Elsherbiny NM, Magmomah AO (2017) Effect of 2-hydroxychalcone on adiponectin level in type 2 diabetes induced experimentally in rats Egyptian Journal of Basic and Applied Sciences, (4):1-8
Samra YA, Saleh HM, Hussein KA, Elsherbiny NM, Ibrahim AS, Elmasry K, Fulzele S, El-Shishtawy MM, Eissa LA, Al-Shabrawey M, Liou GI (2017) Adenosine Deaminase-2-Induced Hyperpermeability in Human Retinal Vascular Endothelial Cells Is Suppressed by MicroRNA-146b-3p Invest Ophthalmol Vis Sci 1 58(2): 933-943
Elsherbiny NM, Maysarah NM, El-Sherbiny M, Al-Gayyar MM (2017) Renal protective effects of thymoquinone against sodium nitrite-induced chronic toxicity in rats: Impact on inflammation and apoptosis Life Sci 180:1-8
Zaghloul RA, Elsherbiny NM, Kenawy HI, El-Karef A, Eissa LA, El-Shishtawy MM (2017) Hepatoprotective effect of hesperidin in hepatocellular carcinoma: Involvement of Wnt signaling pathways Life Sci 185:114-125
El-Mihi KA, Kenawy HI, El-Karef A, Elsherbiny NM, Eissa LA (2017) Naringin attenuates thioacetamide-induced liver fibrosis in rats through modulation of the PI3K/Akt pathway Life Sci 187:50-57
Mohamed R, Sharma I, Ibrahim AS, Saleh H, Elsherbiny NM, Fulzele S, Elmasry K, Smith SB, Al-Shabrawey M, Tawfik A (2017) Hyperhomocysteinemia Alters Retinal Endothelial Cells Barrier Function and Angiogenic Potential via Activation of Oxidative Stress Sci Rep 2017 Sep 207(1):11952
Mira A, Elsherbiny N, Alkhiary W, Shebl A, Tran H, Shimizu K (2017):Hepatoprotective Activities of The Methanol Extract of Angelica shikokiana and Its Major Coumarin: Isoepoxypteryxin against Hepatocellular Carcinoma Indian Journal of Pharmaceutical Sciences 79 (4), 576-584
Said E, Zaitone SA, Eldosoky M, Elsherbiny NM (2018) Nifuroxazide, a STAT3 inhibitor, mitigates inflammatory burden and protects against diabetes-induced nephropathy in rats Chem Biol Interact 281:111-120
Elmasry K, Ibrahim AS, Saleh H, Elsherbiny N, Elshafey S, Hussein KA, Al-Shabrawey M Role of endoplasmic reticulum stress in 12/15-lipoxygenase-induced retinal microvascular dysfunction in a mouse model of diabetic retinopathy (2018)Diabetologia 61(5):1220-1232
Elmasry K, Mohamed R, Sharma I, Elsherbiny NM, Liu Y, Al-Shabrawey M, Tawfik A Epigenetic modifications in hyperhomocysteinemia: potential role in diabetic retinopathy and age-related macular degeneration (2018) Oncotarget 9(16):12562-12590
Elsherbiny NM, Zaitone SA, Mohammad HMF, El-Sherbiny M Renoprotective effect of nifuroxazide in diabetes-induced nephropathy: impact on NFκB, oxidative stress, and apoptosis (2018) Toxicol Mech Methods 28(6):467-473
El-Sherbiny M, Eldosoky M, El-Shafey M, Othman G, Elkattawy HA, Bedir T, Elsherbiny NM (2018) Vitamin D nanoemulsion enhances hepatoprotective effect of conventional vitamin D in rats fed with a high-fat diet Chem Biol Interact 288:65-75
El Kramani N, Elsherbiny NM, El-Gayar AM, Ebrahim MA, Al-Gayyar MMH (2018) Clinical significance of the TNF-α receptors, TNFRSF2 and TNFRSF9, on cell migration molecules Fascin-1 and Versican in acute leukemia Cytokine
Zaitone SA, Ahmed E, Elsherbiny NM, Mehanna ET, El-Kherbetawy MK, ElSayed MH, Alshareef DM, Moustafa YM (2018) Caffeic acid improves locomotor activity and lessens inflammatory burden in a mouse model of rotenone-induced nigral neurodegeneration: Relevance to Parkinson’s disease therapy Pharmacological Reports,
Eissa LA, Kenawy HI, El-Karef A, Elsherbiny NM, El-Mihi KA (2018) Antioxidant and anti-inflammatory activities of berberine attenuate hepatic fibrosis induced by thioacetamide injection in rats Chem Biol Interact 21 294:91-100
Zaitone SA, Ahmed E, Elsherbiny NM, Mehanna ET, El-Kherbetawy MK, ElSayed MH, Alshareef DM, Moustafa YM (2018): Caffeic acid improves locomotor activity and lessens inflammatory burden in a mouse model of rotenone-induced nigral neurodegeneration: Relevance to Parkinsons disease therapy Pharmacol Rep 71(1):32-41
Eisa NH, Said HS, Elsherbiny NM, Eissa LA, El-Shishtawy MM (2019): Phenethyl isothiocyanate Triggers Apoptosis, Combats Oxidative Stress and Inhibits Growth of Ehrlich Ascites Carcinoma Mouse Model Iran J Pharm Res 2018 Fall17(4):1328-1338
Tawfik A, Mohamed R, Elsherbiny NM, DeAngelis MM, Bartoli M, Al-Shabrawey M (2019): Homocysteine: A Potential Biomarker for Diabetic Retinopathy J Clin Med 8(1) pii: E121
Eisa NH, Jilani Y, Kainth K, Redd P, Lu S, Bougrine O, Abdul Sater H, Patwardhan CA, Shull A, Shi H, Liu K, ElSherbiny NM, Eissa LA, El-Shishtawy MM, Horuzsko A, Bollag R, Maihle N, Roig J, Korkaya H, Cowell JK, Chadli A (2019): The co-chaperone UNC45A is essential for the expression of mitotic kinase NEK7 and tumorigenesis J Biol Chem
Elsherbiny NM, Ahmed E, Kader GA, Abdel-Mottaleb Y, ElSayed MH, Youssef AM, Zaitone SA (2019): Inhibitory effect of valproate sodium on pain behavior in diabetic mice involves suppression of spinal histone deacetylase 1 and inflammatory mediators Int Immunopharmacol 70:16-27
Elmarakby AA, Ibrahim AS, Katary MA, Elsherbiny NM, El-Shafey M, Abd-Elrazik AM, Abdelsayed RA, Maddipati KR, Al-Shabrawey M A dual role of 12/15-lipoxygenase in LPS-induced acute renal inflammation and injury Biochim Biophys Acta Mol Cell Biol Lipids 2019 Nov1864(11):1669-1680
Nazmy EA, El-Khouly OA, Zaki MMA, Elsherbiny NM, Said E, Al-Gayyar MMH, Salem HA Targeting p53/TRAIL/caspase-8 signaling by adiponectin reverses thioacetamide-induced hepatocellular carcinoma in rats Environ Toxicol Pharmacol 2019 Aug 772:103240
Elshaer R, Tawfik MK, Nosseir N, El-Ghaiesh SH, Toraih EA, Elsherbiny NM, Zaitone SA Leflunomide-induced liver injury in mice: Involvement of TLR4 mediated activation of PI3K/mTOR/NFκB pathway Life Sci 2019 Aug 30:116824
Elsherbiny NM, Abdel-Mottaleb Y, Elkazaz AY, et al Carbamazepine Alleviates Retinal and Optic Nerve Neural Degeneration in Diabetic Mice via Nerve Growth Factor-Induced PI3K/Akt/mTOR Activation Front Neurosci 201913:1089
Elsherbiny NM, Said E, Atef H, Zaitone SA Renoprotective effect of calycosin in high fat diet-fed/STZ injected rats: Effect on IL-33/ST2 signaling, oxidative stress and fibrosis suppression 2019, Chem Biol Interact 2020315(5)108897
Elsherbiny NM, Sharma I, Kira D, Alhusban S, Samra YA, Jadeja R, Martin P, Al-Shabrawey M, Tawfik A Homocysteine Induces Inflammation in Retina and Brain Biomolecules 202010(3) pii: E393
Alatyyat, SM, Alasmari, HM, Aleid, OA, Abdel-maksoud, MS, Elsherbiny, NM Umbilical cord stem cells: Background, processing and applications Tissue and Cell2020 65, 101351
El-Far YM, Elsherbiny NM, El-Shafey M, Said E The interplay of the inhibitory effect of nifuroxazide on NF-κB/STAT3 signaling attenuates acetic acid-induced ulcerative colitis in rats Environ Toxicol Pharmacol 202079:103433
Alzahrani, S, Zaitone, S A, Said, E, El-Sherbiny, M, Ajwah, S, Alsharif, S Y, & Elsherbiny, N M (2020) Protective effect of isoliquiritigenin on experimental diabetic nephropathy in rats: Impact on Sirt-1/NFκB balance and NLRP3 expression International immunopharmacology, 87, 106813
Alzahrani, S, Ajwah, S M, Alsharif, S Y, Said, E, El-Sherbiny, M, Zaitone, S A, Al-Shabrawey, M, & Elsherbiny, N M (2020) Isoliquiritigenin downregulates miR-195 and attenuates oxidative stress and inflammation in STZ-induced retinal injury Naunyn-Schmiedebergs archives of pharmacology, 101007/s00210-020-01948-5
Younis, N N, Elsherbiny, N M, Shaheen, M A, & Elseweidy, M M (2020) Modulation of NADPH oxidase and Nrf2/HO-1 pathway by vanillin in cisplatin-induced nephrotoxicity in rats The Journal of pharmacy and pharmacology,
Tawfik, A, Samra, Y A, Elsherbiny, N M, & Al-Shabrawey, M (2020) Implication of Hyperhomocysteinemia in Blood Retinal Barrier (BRB) Dysfunction Biomolecules, 10(8), E1119
Elsherbiny, N M, El-Sherbiny, M, & Zaitone, S A (2020) Diallyl trisulfide potentiates chemotherapeutic efficacy of doxorubicin in experimentally induced mammary carcinoma: Role of Notch signaling Pathology, research and practice, 216(10), 153139
Elsherbiny, N M, Eisa, N H, El-Sherbiny, M, & Said, E (2020) Chemo-preventive effect of crocin against experimentally-induced hepatocarcinogenesis via regulation of apoptotic and Nrf2 signaling pathways Environmental toxicology and pharmacology, 80, 103494
Zaitone, S A, Alshaman, R, Alattar, A, Elsherbiny, N M, Abogresha, N M, El-Kherbetawy, M K, Elaskary, A A, Hashish, A A, Rashed, L A, & Ahmed, E (2020) Retinoprotective effect of donepezil in diabetic mice involves mitigation of excitotoxicity and activation of PI3K/mTOR/BCl2 pathway Life sciences, 262, 118467 Advance online publication
Elsherbini, A M, Maysarah, N M, El-Sherbiny, M, Al-Gayyar, M M, & Elsherbiny, N M (2020) Glycyrrhizic acid ameliorates sodium nitrite-induced lung and salivary gland toxicity: Impact on oxidative stress, inflammation and fibrosis Human & experimental toxicology, 960327120964555
Al-Serwi, R H, Othman, G, Attia, M A, Enan, E T, El-Sherbiny, M, Mahmoud, S, & Elsherbiny, N (2020) Enhancement of Cisplatin Cytotoxicity by Cu(II)-Mn(II) Schiff Base Tetradentate Complex in Human Oral Squamous Cell Carcinoma Molecules (Basel, Switzerland), 25(20), 4688
Sherif, I O, Al-Mutabagani, L A, Sabry, D, & Elsherbiny, N M (2020) Antineoplastic Activity of Chrysin against Human Hepatocellular Carcinoma: New Insight on GPC3/SULF2 Axis and lncRNA-AF085935 Expression International journal of molecular sciences, 21(20), 7642
Fahmy, E K, El-Sherbiny, M, Said, E, Elkattawy, H A, Qushawy, M, & Elsherbiny, N (2021) Tranilast ameliorated subchronic silver nanoparticles-induced cerebral toxicity in rats: Effect on TLR4/NLRP3 and Nrf-2 Neurotoxicology, 82, 167–176
Al-Shabrawey, M, Hussein, K, Wang, F, Wan, M, Elmasry, K, Elsherbiny, N, Saleh, H, Yu, P B, Tawfik, A, & Ibrahim, A S (2021) Bone Morphogenetic Protein-2 Induces Non-Canonical Inflammatory and Oxidative Pathways in Human Retinal Endothelial Cells Frontiers in immunology, 11, 568795
Sharifa Alzahrani, Eman Said, Sadeem M Ajwah, Sumayyah Y Alsharif, Khaled S El-Bayoumi, Sawsan A Zaitone, Mona Qushawy, Nehal M Elsherbiny (2021) Isoliquiritigenin attenuates inflammation and modulates Nrf2/caspase-3 signalling in STZ-induced aortic injury, Journal of Pharmacy and Pharmacology, 73 (2): 193–205
Alzhrani GN, Alanazi ST, Alsharif SY, Albalawi AM, Alsharif AA, Abdel-Maksoud MS, Elsherbiny N Exosomes: Isolation, characterization, and biomedical applications Cell Biol Int 2021 Apr 29 doi: 101002/cbin11620
Tawfik A, Elsherbiny NM, Zaidi Y, Rajpurohit P Homocysteine and Age-Related Central Nervous System Diseases: Role of Inflammation Int J Mol Sci 2021 Jun 1022(12):6259 doi: 103390/ijms22126259
Eisa NH, Khodir AE, El-Sherbiny M, Elsherbiny NM, Said E Phenethyl isothiocyanate attenuates diabetic nephropathy via modulation of glycative/oxidative/inflammatory signaling in diabetic rats Biomed Pharmacother 2021 Jun 29:111666 doi: 101016/jbiopha2021111666
Agha KA, Ibrahim TS, Elsherbiny NM, El-Sherbiny M, Abdel-Aal EH, Abdel-Samii ZK, Abo-Dya NE Design, synthesis and pharmacological screening of novel renoprotective methionine-based peptidomimetics: Amelioration of cisplatin-induced nephrotoxicity Bioorg Chem 2021 Jun 17114:105100 doi: 101016/jbioorg2021105100
Ebrahim N, Dessouky AA, Mostafa O, Hassouna A, Yousef MM, Seleem Y, El Gebaly EAEAM, Allam MM, Farid AS, Saffaf BA, Sabry D, Nawar A, Shoulah AA, Khalil AH, Abdalla SF, El-Sherbiny M, Elsherbiny NM, Salim RF Adipose mesenchymal stem cells combined with platelet-rich plasma accelerate diabetic wound healing by modulating the Notch pathway Stem Cell Res Ther 2021 Jul 1312(1):392 doi: 101186/s13287-021-02454-y
El-Sherbiny M, El-Shafey M, El-Din El-Agawy MS, Mohamed AS, Eisa NH, Elsherbiny NM Diacerein ameliorates testosterone-induced benign prostatic hyperplasia in rats: Effect on oxidative stress, inflammation and apoptosis Int Immunopharmacol 2021 Aug 24100:108082 doi: 101016/jintimp2021108082
El-Sherbiny M, Eisa NH, Abo El-Magd NF, Elsherbiny NM, Said E, Khodir AE Anti-inflammatory/anti-apoptotic impact of betulin attenuates experimentally induced ulcerative colitis: An insight into TLR4/NF-kB/caspase signalling modulation Environ Toxicol Pharmacol 202188:103750
Said Ahmed WM, Elsherbini AM, Elsherbiny NM, El-Sherbiny M, Ramzy NI, Arafa AF Maxillary Mucormycosis Osteomyelitis in Post COVID-19 Patients: A Series of Fourteen Cases Diagnostics (Basel) 202111(11):2050
Ebrahim N, Badr OAM, Yousef MM, Hassouna A, Sabry D, Farid AS, Mostafa O, Saihati HAA, Seleem Y, Abd El Aziz E, Khalil AH, Nawar A, Shoulah AA, Aljasir M, Mohamed AZ, El-Sherbiny M, Elsherbiny NM, Eladl MA, Forsyth NR, Salim RF Functional Recellularization of Acellular Rat Liver Scaffold by Induced Pluripotent Stem Cells: Molecular Evidence for Wnt/B-Catenin Upregulation Cells 2021 Oct 2010(11):2819
El-Sherbiny M, Fahmy EK, Eisa NH, Said E, Elkattawy HA, Ebrahim HA, Elsherbiny NM, Ghoneim FM Nanogold Particles Suppresses 5-Flurouracil-Induced Renal Injury: An Insight into the Modulation of Nrf-2 and Its Downstream Targets, HO-1 and γ-GCS Molecules 2021 Dec 1926(24):76
4 Elsherbiny NM, Abdel-Maksoud MS, Prabahar K, Mohammedsaleh ZM, Badr OAM, Dessouky AA, Salem HA, Refadah OA, Farid AS, Shamaa AA, Ebrahim N MSCs-derived EVs protect against chemotherapy-induced ovarian toxicity: role of PI3K/AKT/mTOR axis J Ovarian Res 2024 Nov 1117(1):222 doi: 101186/s13048-024-01545-7 PMID: 39529187 PMCID: PMC11552115
3 Ahmed R, Alghamdi WN, Alharbi FR, Alatawi HD, Alenezi KM, Alanazi TF, Elsherbiny NM CRISPR/Cas9 System as a Promising Therapy in Thalassemia and Sickle Cell Disease: A Systematic Review of Clinical Trials Mol Biotechnol 2025 Jan 10 doi: 101007/s12033-025-01368-x Epub ahead of print PMID: 39794549
2 Abdel-Maksoud MS, Alatawi RA, Albalawi SSA, Alrashidi MN, Abo-Dya NE, Elsherbiny N, Ragab YM, Awaji AA, El-Sherbiny M, Elfadil H, Abd-Alhaseeb MM Diacereins antiproliferative effects alone and with 5-fluorouracil in an Ehrlich solid tumour model: Molecular docking, molecular dynamics Simulation studies, and experimental Verification Eur J Pharmacol 2025 Jun 5996:177564 doi: 101016/jejphar2025177564 Epub 2025 Mar 27 PMID: 40157706
1 Qushawy M, Alanazi MA, Hikal WM, Amirthalingam P, Abu-Gharbieh E, Almanzalawi WS, Mortagi Y, Elsherbiny N, Elsherbini AM Optimized Nanostructured Lipid Carriers for Metformin: Enhanced Anti-Inflammatory Activity and Protection Against Type 2 Diabetes-Induced Organ Damage Int J Nanomedicine 2025 Mar 2420:3765-3788 doi: 102147/IJNS506631 PMID: 40162331 PMCID: PMC11952062

Project Name	Project Description
Possible cytotoxic effect of allantoin on oral squamous cell carcinoma stemness (in vivo and in vitro model)	Funded by Research unit, AlMaarefa University, Riyadh, Saudi Arabia
Targeting IL-6/STAT3/ lncRNA HOTAIR axis for treatment of colorectal cancer	Funded by Research unit, AlMaarefa University, Riyadh, Saudi Arabia
Novel Strategy for Alleviating Diabetic Complications: Targeting Sirt-1 for renal, retinal and arterial injury	Funded by Deanship of Scientific Research, University of Tabuk, Tabuk, Saudi Arabia
Development of new strategies for treatment of breast cancer: Implication of Notch signaling	Funded by Deanship of Scientific Research, University of Tabuk, Tabuk, Saudi Arabia
Neuroprotective effect of donepezil against diabetic retinopathy and optic nerve damage: possible downregulation of glutamate receptors and modulation of AMPK/mTOR pathway	Funded by Deanship of Scientific Research, University of Tabuk, Tabuk, Saudi Arabia
Effect of Calycocin on Diabetic Nephropathy: Implication of IL-33/ST2 Signaling Pathway	Funded by Deanship of Scientific Research, University of Tabuk, Tabuk, Saudi Arabia
Role of Valproate sodium in alloxan diabetic mice: influence on spinal histone deacetylase inhibition and glia reactivity	Funded by Deanship of Scientific Research, University of Tabuk, Tabuk, Saudi Arabia
Study of the reno-protective effect of nifuroxazide in diabetic nephropathy	Funded by Deanship of Scientific Research, University of Tabuk, Tabuk, Saudi Arabia
Protective effect of Caffeic acid phenethyl ester against rotenone-induced neurodegeneration: implication for Parkinson’s disease therapy	Funded by Deanship of Scientific Research, University of Tabuk, Tabuk, Saudi Arabia
Control of heparin Sulfate Proteoglycans degradation: New therapy for Hepatocellular Carcinoma	Funded by Mansoura University, Mansoura, Egypt
Design and development of polymer coated microneedle-mediated delivery of β-sitosterol for the treatment of androgenic alopecia	Funded by Ministry of High Education, Saudi Arabia
Sleep Deprivation-Induced Brain Deficits in Naturally Aged Rats and Role of Oxytocin: Behavioral, Cognitive, And Molecular Evidence	Hevolution Foundation, Riyadh, Saudi Arabia, 2023
Unlocking the Link: Nutritional Deficiency and Blood Barrier Dysfunction in Aging Eye and Brain, Unveiling the Role of TRP Channels, Ca+2 Influx, and Stress Pathways	Hevolution Foundation, Riyadh, Saudi Arabia, 2025

College

Faculty of Pharmacy

General specialization

Pharmaceutical Analytical Chemistry

Exact Specialty

Computational Chemistry

Academic degree (rank)

Doctorate

Nationality

Egyptian

Job Title

Assoc. Prof.

Last Modified Date:2026/01/25 - 07:13 AM06/Sha’ban/1447 - 10:13Saudi Arabia Time

Elsherbiny NM, Abd El Galil KH, Gabr MM, Al-Gayyar MM, Eissa LA, El-Shishtawy MM (2012) Reno-protective effect of NECA in diabetic nephropathy: implication of IL-18 and ICAM-1 Eur Cytokine Netw, 23(3): 78-86
Al-Gayyar MM, Elsherbiny NM (2013) Contribution of TNF-α to the development of retinal neurodegenerative disorders Eur Cytokine Netw, 24(1): 27-36
Elsherbiny NM, Ahmad S, Naime M, Elsherbini AM, Fulzele S, Al-Gayyar MM, Eissa LA, El-Shishtawy MM, Liou GI (2013) ABT-702, an adenosine kinase inhibitor, attenuates inflammation in diabetic retinopathy Life Sci, 93 (2-3): 78-88
Elsherbiny NM, Naime M, Ahmad S, Elsherbini AM, Mohammad S, Fulzele S, El-Remessy AB, Al-Gayyar MM, Eissa LA, El-Shishtawy MM, Han G, White R, Haroldo TF, Liou GI (2013) Potential roles of adenosine deaminase-2 in diabetic retinopathy Biochem Biophys Res Commun, 436(3): 355-61
Elsherbiny NM, Al-Gayyar MM (2013) Adenosine Receptors: New Therapeutic Targets for Inflammation in Diabetic Nephropathy Inflamm Allergy Drug Targets, 12(3):153-61
Ahmad S, Fatteh N, El-Sherbiny NM, Naime M, Ibrahim AS, El-Sherbini AM, El-Shafey SA, Khan S, Fulzele S, Gonzales J, Liou GI (2013) Potential role of A2A adenosine receptor in traumatic optic neuropathy J Neuroimmunol, 264(1-2):54-64
Bayomi HS, Elsherbiny NM, El-Gayar AM, Al-Gayyar MM (2013) Evaluation of renal protective effects of inhibiting TGF-β type I receptor in a cisplatin-induced nephrotoxicity model Eur Cytokine Netw 24(4):139-47
Ahmad S, Fatteh N, El-Sherbiny NM, Naime M, Ibrahim AS, El-Sherbini AM, El-Shafey SA, Khan S, Fulzele S, Gonzales J, Liou GI (2013) Potential role of A2A adenosine receptor in traumatic optic neuropathy J Neuroimmunol, 264(1-2):54-64
Bayomi HS, Elsherbiny NM, El-Gayar AM, Al-Gayyar MM (2013) Evaluation of renal protective effects of inhibiting TGF-β type I receptor in a cisplatin-induced nephrotoxicity model Eur Cytokine Netw 24(4):139-47
Pye C, Elsherbiny NM, Ibrahim AS, Liou GI, Chadli A, Elmarakby AA (2014) Adenosine Kinase Inhibition Protects The Kidney Against Streptozotocin-Induced Diabetes Through Anti-inflammatory and Anti-oxidant Mechanisms Pharmacological research, Pharmacol Res 85:45-54
Ahmad S, Elsherbiny NM, Haque R, Khan MB, Ishrat T, Shah ZA, Khan MM, Ali M, Jamal A, Katare DP, Liou GI, Bhatia K (2014) Sesamin attenuates neurotoxicity in mouse model of ischemic brain stroke Neurotoxicology, 45:100-10
Ahmad S, El-Sherbiny NM, Bhatia k, El-Sherbini A, Fulzele S, Liou GI (2014) Inhibition of adenosine kinase attenuates inflammation and neurotoxicity in traumatic optic neuropathy J of Neuroimmunology, 277(1-2):96-104
El Kramani N, Elsherbiny NM, El-Gayar AM, Ebrahim MA, Al-Gayyar MM (2015) Tumor Necrosis Factor Receptor 2: Its Clinical Significance and Clinicopathologic Correlation in acute leukemias Journal of Applied Pharmaceutical Science, 5 (11): 79-83
El Kramani N, Elsherbiny NM, El-Gayar AM, Ebrahim MA, Al-Gayyar MM (2015) Evaluation of Leukocytes Tumor Necrosis Factor Receptor 2 in Acute Leukemia Patients Clinical Research and Development, 2 (2): 155-120
Eissa LA, Elsherbiny NM, Magmomah AO (2015) Propolis restored adiponectin level in type 2 diabetes through PPARγ activation Egyptian Journal of Basic and Applied Sciences, 2 (4): 318–326
Elsherbiny NM, El-Sherbiny M, Said E (2015) Amelioration of experimentally induced diabetic nephropathy and renal damage by nilotinib J Physiol Biochem 71(4): 635-48
Eisa NH, ElSherbiny NM, Shebl AM, Eissa LA, El-Shishtawy MM (2015) Phenethyl isothiocyanate potentiates anti-tumour effect of doxorubicin through Akt-dependent pathway Cell Biochem Funct 33(8): 541-51
Elsherbiny NM, Al-Gayyar MM, Abd El Galil KH (2015) Nephroprotective role of dipyridamole in diabetic nephropathy: Effect on inflammation and apoptosis Life Sci 143:8-17
Elsherbiny NM, Eladl MA, Al-Gayyar MM (2016) Renal protective effects of arjunolic acid in a cisplatin-induced nephrotoxicity model Cytokine 77:26-34
Elsherbiny NM, Al-Gayyar MM (2016) The role of IL-18 in type 1 diabetic nephropathy: The problem and future treatment Cytokine 81:15-22
Ibrahim AS, Mander S, Hussein KA, Elsherbiny NM, Smith SB, Al-Shabrawey M, Tawfik A (2016) Hyperhomocysteinemia disrupts retinal pigment epithelial structure and function with features of age-related macular degeneration Oncotarget 7(8):8532-45
Elsherbiny NM, Salama MF, Said E, El-Sherbiny M, Al-Gayyar MM (2016) Crocin protects against doxorubicin-induced myocardial toxicity in rats through down-regulation of inflammatory and apoptic pathways Chem Biol Interact 247:39-48
Alsheblak M, Elsherbiny NM, El-Karef A, El-Shishtawy M (2016) Protective effects of L-carnosine on CCl4 –induced hepatic injury in rats Eur Cytokine Netw 27(1): 6-15
Ahmad S, Elsherbiny NM, Jamal MS, Al-Zahrani FA, Haque R, Khan R, Zaidi SK, Al-Qahtani MH, Liou GI, Bhatia K (2016) Anti-inflammatory role of sesamin in STZ induced mice model of diabetic retinopathy Journal of Neuroimmunology 295-296:47-53
Samra YA, Said HS, Elsherbiny NM, Liou GI, El-Shishtawy MM, Eissa LA (2016) Cepharanthine and Piperine ameliorate diabetic nephropathy in rats: role of NF-κB and NLRP3 inflammasome Life Sci 157:187-99
Elsherbiny NM, Al-Gayyar MM (2016) Anti-tumor activity of arjunolic acid against Ehrlich Ascites Carcinoma cells in vivo and in vitro through blocking TGF-β type 1 receptor Biomed Pharmacother 82:28-34
Elsherbiny NM, Younis NN, Shaheen MA, Elseweidy MM (2016) The synergistic effect between vanillin and doxorubicin in ehrlich ascites carcinoma solid tumor and MCF-7 human breast cancer cell line Pathol Res Pract 212(9):767-77
Arffa ML, Zapf MA, Kothari AN, Chang V, Gupta GN, Ding X, Al-Gayyar MM, Syn W, Elsherbiny NM, Kuo PC, Mi Z (2016) Epigallocatechin-3-Gallate Upregulates miR-221 to Inhibit Osteopontin-Dependent Hepatic Fibrosis PLoS One 11(12):e0167435
Elfar GA, Ebrahim ME, Elsherbiny NM, Eissa LA (2016) Validity of osteoprotegerin and receptor activator of NF-κB ligand for detection of bone metastasis in breast cancer Oncol Res 25(4):641-650
Eissa LA, Elsherbiny NM, Magmomah AO (2017) Effect of 2-hydroxychalcone on adiponectin level in type 2 diabetes induced experimentally in rats Egyptian Journal of Basic and Applied Sciences, (4):1-8
Samra YA, Saleh HM, Hussein KA, Elsherbiny NM, Ibrahim AS, Elmasry K, Fulzele S, El-Shishtawy MM, Eissa LA, Al-Shabrawey M, Liou GI (2017) Adenosine Deaminase-2-Induced Hyperpermeability in Human Retinal Vascular Endothelial Cells Is Suppressed by MicroRNA-146b-3p Invest Ophthalmol Vis Sci 1 58(2): 933-943
Elsherbiny NM, Maysarah NM, El-Sherbiny M, Al-Gayyar MM (2017) Renal protective effects of thymoquinone against sodium nitrite-induced chronic toxicity in rats: Impact on inflammation and apoptosis Life Sci 180:1-8
Zaghloul RA, Elsherbiny NM, Kenawy HI, El-Karef A, Eissa LA, El-Shishtawy MM (2017) Hepatoprotective effect of hesperidin in hepatocellular carcinoma: Involvement of Wnt signaling pathways Life Sci 185:114-125
El-Mihi KA, Kenawy HI, El-Karef A, Elsherbiny NM, Eissa LA (2017) Naringin attenuates thioacetamide-induced liver fibrosis in rats through modulation of the PI3K/Akt pathway Life Sci 187:50-57
Mohamed R, Sharma I, Ibrahim AS, Saleh H, Elsherbiny NM, Fulzele S, Elmasry K, Smith SB, Al-Shabrawey M, Tawfik A (2017) Hyperhomocysteinemia Alters Retinal Endothelial Cells Barrier Function and Angiogenic Potential via Activation of Oxidative Stress Sci Rep 2017 Sep 207(1):11952
Mira A, Elsherbiny N, Alkhiary W, Shebl A, Tran H, Shimizu K (2017):Hepatoprotective Activities of The Methanol Extract of Angelica shikokiana and Its Major Coumarin: Isoepoxypteryxin against Hepatocellular Carcinoma Indian Journal of Pharmaceutical Sciences 79 (4), 576-584
Said E, Zaitone SA, Eldosoky M, Elsherbiny NM (2018) Nifuroxazide, a STAT3 inhibitor, mitigates inflammatory burden and protects against diabetes-induced nephropathy in rats Chem Biol Interact 281:111-120
Elmasry K, Ibrahim AS, Saleh H, Elsherbiny N, Elshafey S, Hussein KA, Al-Shabrawey M Role of endoplasmic reticulum stress in 12/15-lipoxygenase-induced retinal microvascular dysfunction in a mouse model of diabetic retinopathy (2018)Diabetologia 61(5):1220-1232
Elmasry K, Mohamed R, Sharma I, Elsherbiny NM, Liu Y, Al-Shabrawey M, Tawfik A Epigenetic modifications in hyperhomocysteinemia: potential role in diabetic retinopathy and age-related macular degeneration (2018) Oncotarget 9(16):12562-12590
Elsherbiny NM, Zaitone SA, Mohammad HMF, El-Sherbiny M Renoprotective effect of nifuroxazide in diabetes-induced nephropathy: impact on NFκB, oxidative stress, and apoptosis (2018) Toxicol Mech Methods 28(6):467-473
El-Sherbiny M, Eldosoky M, El-Shafey M, Othman G, Elkattawy HA, Bedir T, Elsherbiny NM (2018) Vitamin D nanoemulsion enhances hepatoprotective effect of conventional vitamin D in rats fed with a high-fat diet Chem Biol Interact 288:65-75
El Kramani N, Elsherbiny NM, El-Gayar AM, Ebrahim MA, Al-Gayyar MMH (2018) Clinical significance of the TNF-α receptors, TNFRSF2 and TNFRSF9, on cell migration molecules Fascin-1 and Versican in acute leukemia Cytokine
Zaitone SA, Ahmed E, Elsherbiny NM, Mehanna ET, El-Kherbetawy MK, ElSayed MH, Alshareef DM, Moustafa YM (2018) Caffeic acid improves locomotor activity and lessens inflammatory burden in a mouse model of rotenone-induced nigral neurodegeneration: Relevance to Parkinson’s disease therapy Pharmacological Reports,
Eissa LA, Kenawy HI, El-Karef A, Elsherbiny NM, El-Mihi KA (2018) Antioxidant and anti-inflammatory activities of berberine attenuate hepatic fibrosis induced by thioacetamide injection in rats Chem Biol Interact 21 294:91-100
Zaitone SA, Ahmed E, Elsherbiny NM, Mehanna ET, El-Kherbetawy MK, ElSayed MH, Alshareef DM, Moustafa YM (2018): Caffeic acid improves locomotor activity and lessens inflammatory burden in a mouse model of rotenone-induced nigral neurodegeneration: Relevance to Parkinsons disease therapy Pharmacol Rep 71(1):32-41
Eisa NH, Said HS, Elsherbiny NM, Eissa LA, El-Shishtawy MM (2019): Phenethyl isothiocyanate Triggers Apoptosis, Combats Oxidative Stress and Inhibits Growth of Ehrlich Ascites Carcinoma Mouse Model Iran J Pharm Res 2018 Fall17(4):1328-1338
Tawfik A, Mohamed R, Elsherbiny NM, DeAngelis MM, Bartoli M, Al-Shabrawey M (2019): Homocysteine: A Potential Biomarker for Diabetic Retinopathy J Clin Med 8(1) pii: E121
Eisa NH, Jilani Y, Kainth K, Redd P, Lu S, Bougrine O, Abdul Sater H, Patwardhan CA, Shull A, Shi H, Liu K, ElSherbiny NM, Eissa LA, El-Shishtawy MM, Horuzsko A, Bollag R, Maihle N, Roig J, Korkaya H, Cowell JK, Chadli A (2019): The co-chaperone UNC45A is essential for the expression of mitotic kinase NEK7 and tumorigenesis J Biol Chem
Elsherbiny NM, Ahmed E, Kader GA, Abdel-Mottaleb Y, ElSayed MH, Youssef AM, Zaitone SA (2019): Inhibitory effect of valproate sodium on pain behavior in diabetic mice involves suppression of spinal histone deacetylase 1 and inflammatory mediators Int Immunopharmacol 70:16-27
Elmarakby AA, Ibrahim AS, Katary MA, Elsherbiny NM, El-Shafey M, Abd-Elrazik AM, Abdelsayed RA, Maddipati KR, Al-Shabrawey M A dual role of 12/15-lipoxygenase in LPS-induced acute renal inflammation and injury Biochim Biophys Acta Mol Cell Biol Lipids 2019 Nov1864(11):1669-1680
Nazmy EA, El-Khouly OA, Zaki MMA, Elsherbiny NM, Said E, Al-Gayyar MMH, Salem HA Targeting p53/TRAIL/caspase-8 signaling by adiponectin reverses thioacetamide-induced hepatocellular carcinoma in rats Environ Toxicol Pharmacol 2019 Aug 772:103240
Elshaer R, Tawfik MK, Nosseir N, El-Ghaiesh SH, Toraih EA, Elsherbiny NM, Zaitone SA Leflunomide-induced liver injury in mice: Involvement of TLR4 mediated activation of PI3K/mTOR/NFκB pathway Life Sci 2019 Aug 30:116824
Elsherbiny NM, Abdel-Mottaleb Y, Elkazaz AY, et al Carbamazepine Alleviates Retinal and Optic Nerve Neural Degeneration in Diabetic Mice via Nerve Growth Factor-Induced PI3K/Akt/mTOR Activation Front Neurosci 201913:1089
Elsherbiny NM, Said E, Atef H, Zaitone SA Renoprotective effect of calycosin in high fat diet-fed/STZ injected rats: Effect on IL-33/ST2 signaling, oxidative stress and fibrosis suppression 2019, Chem Biol Interact 2020315(5)108897
Elsherbiny NM, Sharma I, Kira D, Alhusban S, Samra YA, Jadeja R, Martin P, Al-Shabrawey M, Tawfik A Homocysteine Induces Inflammation in Retina and Brain Biomolecules 202010(3) pii: E393
Alatyyat, SM, Alasmari, HM, Aleid, OA, Abdel-maksoud, MS, Elsherbiny, NM Umbilical cord stem cells: Background, processing and applications Tissue and Cell2020 65, 101351
El-Far YM, Elsherbiny NM, El-Shafey M, Said E The interplay of the inhibitory effect of nifuroxazide on NF-κB/STAT3 signaling attenuates acetic acid-induced ulcerative colitis in rats Environ Toxicol Pharmacol 202079:103433
Alzahrani, S, Zaitone, S A, Said, E, El-Sherbiny, M, Ajwah, S, Alsharif, S Y, & Elsherbiny, N M (2020) Protective effect of isoliquiritigenin on experimental diabetic nephropathy in rats: Impact on Sirt-1/NFκB balance and NLRP3 expression International immunopharmacology, 87, 106813
Alzahrani, S, Ajwah, S M, Alsharif, S Y, Said, E, El-Sherbiny, M, Zaitone, S A, Al-Shabrawey, M, & Elsherbiny, N M (2020) Isoliquiritigenin downregulates miR-195 and attenuates oxidative stress and inflammation in STZ-induced retinal injury Naunyn-Schmiedebergs archives of pharmacology, 101007/s00210-020-01948-5
Younis, N N, Elsherbiny, N M, Shaheen, M A, & Elseweidy, M M (2020) Modulation of NADPH oxidase and Nrf2/HO-1 pathway by vanillin in cisplatin-induced nephrotoxicity in rats The Journal of pharmacy and pharmacology,
Tawfik, A, Samra, Y A, Elsherbiny, N M, & Al-Shabrawey, M (2020) Implication of Hyperhomocysteinemia in Blood Retinal Barrier (BRB) Dysfunction Biomolecules, 10(8), E1119
Elsherbiny, N M, El-Sherbiny, M, & Zaitone, S A (2020) Diallyl trisulfide potentiates chemotherapeutic efficacy of doxorubicin in experimentally induced mammary carcinoma: Role of Notch signaling Pathology, research and practice, 216(10), 153139
Elsherbiny, N M, Eisa, N H, El-Sherbiny, M, & Said, E (2020) Chemo-preventive effect of crocin against experimentally-induced hepatocarcinogenesis via regulation of apoptotic and Nrf2 signaling pathways Environmental toxicology and pharmacology, 80, 103494
Zaitone, S A, Alshaman, R, Alattar, A, Elsherbiny, N M, Abogresha, N M, El-Kherbetawy, M K, Elaskary, A A, Hashish, A A, Rashed, L A, & Ahmed, E (2020) Retinoprotective effect of donepezil in diabetic mice involves mitigation of excitotoxicity and activation of PI3K/mTOR/BCl2 pathway Life sciences, 262, 118467 Advance online publication
Elsherbini, A M, Maysarah, N M, El-Sherbiny, M, Al-Gayyar, M M, & Elsherbiny, N M (2020) Glycyrrhizic acid ameliorates sodium nitrite-induced lung and salivary gland toxicity: Impact on oxidative stress, inflammation and fibrosis Human & experimental toxicology, 960327120964555
Al-Serwi, R H, Othman, G, Attia, M A, Enan, E T, El-Sherbiny, M, Mahmoud, S, & Elsherbiny, N (2020) Enhancement of Cisplatin Cytotoxicity by Cu(II)-Mn(II) Schiff Base Tetradentate Complex in Human Oral Squamous Cell Carcinoma Molecules (Basel, Switzerland), 25(20), 4688
Sherif, I O, Al-Mutabagani, L A, Sabry, D, & Elsherbiny, N M (2020) Antineoplastic Activity of Chrysin against Human Hepatocellular Carcinoma: New Insight on GPC3/SULF2 Axis and lncRNA-AF085935 Expression International journal of molecular sciences, 21(20), 7642
Fahmy, E K, El-Sherbiny, M, Said, E, Elkattawy, H A, Qushawy, M, & Elsherbiny, N (2021) Tranilast ameliorated subchronic silver nanoparticles-induced cerebral toxicity in rats: Effect on TLR4/NLRP3 and Nrf-2 Neurotoxicology, 82, 167–176
Al-Shabrawey, M, Hussein, K, Wang, F, Wan, M, Elmasry, K, Elsherbiny, N, Saleh, H, Yu, P B, Tawfik, A, & Ibrahim, A S (2021) Bone Morphogenetic Protein-2 Induces Non-Canonical Inflammatory and Oxidative Pathways in Human Retinal Endothelial Cells Frontiers in immunology, 11, 568795
Sharifa Alzahrani, Eman Said, Sadeem M Ajwah, Sumayyah Y Alsharif, Khaled S El-Bayoumi, Sawsan A Zaitone, Mona Qushawy, Nehal M Elsherbiny (2021) Isoliquiritigenin attenuates inflammation and modulates Nrf2/caspase-3 signalling in STZ-induced aortic injury, Journal of Pharmacy and Pharmacology, 73 (2): 193–205
Alzhrani GN, Alanazi ST, Alsharif SY, Albalawi AM, Alsharif AA, Abdel-Maksoud MS, Elsherbiny N Exosomes: Isolation, characterization, and biomedical applications Cell Biol Int 2021 Apr 29 doi: 101002/cbin11620
Tawfik A, Elsherbiny NM, Zaidi Y, Rajpurohit P Homocysteine and Age-Related Central Nervous System Diseases: Role of Inflammation Int J Mol Sci 2021 Jun 1022(12):6259 doi: 103390/ijms22126259
Eisa NH, Khodir AE, El-Sherbiny M, Elsherbiny NM, Said E Phenethyl isothiocyanate attenuates diabetic nephropathy via modulation of glycative/oxidative/inflammatory signaling in diabetic rats Biomed Pharmacother 2021 Jun 29:111666 doi: 101016/jbiopha2021111666
Agha KA, Ibrahim TS, Elsherbiny NM, El-Sherbiny M, Abdel-Aal EH, Abdel-Samii ZK, Abo-Dya NE Design, synthesis and pharmacological screening of novel renoprotective methionine-based peptidomimetics: Amelioration of cisplatin-induced nephrotoxicity Bioorg Chem 2021 Jun 17114:105100 doi: 101016/jbioorg2021105100
Ebrahim N, Dessouky AA, Mostafa O, Hassouna A, Yousef MM, Seleem Y, El Gebaly EAEAM, Allam MM, Farid AS, Saffaf BA, Sabry D, Nawar A, Shoulah AA, Khalil AH, Abdalla SF, El-Sherbiny M, Elsherbiny NM, Salim RF Adipose mesenchymal stem cells combined with platelet-rich plasma accelerate diabetic wound healing by modulating the Notch pathway Stem Cell Res Ther 2021 Jul 1312(1):392 doi: 101186/s13287-021-02454-y
El-Sherbiny M, El-Shafey M, El-Din El-Agawy MS, Mohamed AS, Eisa NH, Elsherbiny NM Diacerein ameliorates testosterone-induced benign prostatic hyperplasia in rats: Effect on oxidative stress, inflammation and apoptosis Int Immunopharmacol 2021 Aug 24100:108082 doi: 101016/jintimp2021108082
El-Sherbiny M, Eisa NH, Abo El-Magd NF, Elsherbiny NM, Said E, Khodir AE Anti-inflammatory/anti-apoptotic impact of betulin attenuates experimentally induced ulcerative colitis: An insight into TLR4/NF-kB/caspase signalling modulation Environ Toxicol Pharmacol 202188:103750
Said Ahmed WM, Elsherbini AM, Elsherbiny NM, El-Sherbiny M, Ramzy NI, Arafa AF Maxillary Mucormycosis Osteomyelitis in Post COVID-19 Patients: A Series of Fourteen Cases Diagnostics (Basel) 202111(11):2050
Ebrahim N, Badr OAM, Yousef MM, Hassouna A, Sabry D, Farid AS, Mostafa O, Saihati HAA, Seleem Y, Abd El Aziz E, Khalil AH, Nawar A, Shoulah AA, Aljasir M, Mohamed AZ, El-Sherbiny M, Elsherbiny NM, Eladl MA, Forsyth NR, Salim RF Functional Recellularization of Acellular Rat Liver Scaffold by Induced Pluripotent Stem Cells: Molecular Evidence for Wnt/B-Catenin Upregulation Cells 2021 Oct 2010(11):2819
El-Sherbiny M, Fahmy EK, Eisa NH, Said E, Elkattawy HA, Ebrahim HA, Elsherbiny NM, Ghoneim FM Nanogold Particles Suppresses 5-Flurouracil-Induced Renal Injury: An Insight into the Modulation of Nrf-2 and Its Downstream Targets, HO-1 and γ-GCS Molecules 2021 Dec 1926(24):76
4 Elsherbiny NM, Abdel-Maksoud MS, Prabahar K, Mohammedsaleh ZM, Badr OAM, Dessouky AA, Salem HA, Refadah OA, Farid AS, Shamaa AA, Ebrahim N MSCs-derived EVs protect against chemotherapy-induced ovarian toxicity: role of PI3K/AKT/mTOR axis J Ovarian Res 2024 Nov 1117(1):222 doi: 101186/s13048-024-01545-7 PMID: 39529187 PMCID: PMC11552115
3 Ahmed R, Alghamdi WN, Alharbi FR, Alatawi HD, Alenezi KM, Alanazi TF, Elsherbiny NM CRISPR/Cas9 System as a Promising Therapy in Thalassemia and Sickle Cell Disease: A Systematic Review of Clinical Trials Mol Biotechnol 2025 Jan 10 doi: 101007/s12033-025-01368-x Epub ahead of print PMID: 39794549
2 Abdel-Maksoud MS, Alatawi RA, Albalawi SSA, Alrashidi MN, Abo-Dya NE, Elsherbiny N, Ragab YM, Awaji AA, El-Sherbiny M, Elfadil H, Abd-Alhaseeb MM Diacereins antiproliferative effects alone and with 5-fluorouracil in an Ehrlich solid tumour model: Molecular docking, molecular dynamics Simulation studies, and experimental Verification Eur J Pharmacol 2025 Jun 5996:177564 doi: 101016/jejphar2025177564 Epub 2025 Mar 27 PMID: 40157706
1 Qushawy M, Alanazi MA, Hikal WM, Amirthalingam P, Abu-Gharbieh E, Almanzalawi WS, Mortagi Y, Elsherbiny N, Elsherbini AM Optimized Nanostructured Lipid Carriers for Metformin: Enhanced Anti-Inflammatory Activity and Protection Against Type 2 Diabetes-Induced Organ Damage Int J Nanomedicine 2025 Mar 2420:3765-3788 doi: 102147/IJNS506631 PMID: 40162331 PMCID: PMC11952062

Project Name	Project Description
Possible cytotoxic effect of allantoin on oral squamous cell carcinoma stemness (in vivo and in vitro model)	Funded by Research unit, AlMaarefa University, Riyadh, Saudi Arabia
Targeting IL-6/STAT3/ lncRNA HOTAIR axis for treatment of colorectal cancer	Funded by Research unit, AlMaarefa University, Riyadh, Saudi Arabia
Novel Strategy for Alleviating Diabetic Complications: Targeting Sirt-1 for renal, retinal and arterial injury	Funded by Deanship of Scientific Research, University of Tabuk, Tabuk, Saudi Arabia
Development of new strategies for treatment of breast cancer: Implication of Notch signaling	Funded by Deanship of Scientific Research, University of Tabuk, Tabuk, Saudi Arabia
Neuroprotective effect of donepezil against diabetic retinopathy and optic nerve damage: possible downregulation of glutamate receptors and modulation of AMPK/mTOR pathway	Funded by Deanship of Scientific Research, University of Tabuk, Tabuk, Saudi Arabia
Effect of Calycocin on Diabetic Nephropathy: Implication of IL-33/ST2 Signaling Pathway	Funded by Deanship of Scientific Research, University of Tabuk, Tabuk, Saudi Arabia
Role of Valproate sodium in alloxan diabetic mice: influence on spinal histone deacetylase inhibition and glia reactivity	Funded by Deanship of Scientific Research, University of Tabuk, Tabuk, Saudi Arabia
Study of the reno-protective effect of nifuroxazide in diabetic nephropathy	Funded by Deanship of Scientific Research, University of Tabuk, Tabuk, Saudi Arabia
Protective effect of Caffeic acid phenethyl ester against rotenone-induced neurodegeneration: implication for Parkinson’s disease therapy	Funded by Deanship of Scientific Research, University of Tabuk, Tabuk, Saudi Arabia
Control of heparin Sulfate Proteoglycans degradation: New therapy for Hepatocellular Carcinoma	Funded by Mansoura University, Mansoura, Egypt
Design and development of polymer coated microneedle-mediated delivery of β-sitosterol for the treatment of androgenic alopecia	Funded by Ministry of High Education, Saudi Arabia
Sleep Deprivation-Induced Brain Deficits in Naturally Aged Rats and Role of Oxytocin: Behavioral, Cognitive, And Molecular Evidence	Hevolution Foundation, Riyadh, Saudi Arabia, 2023
Unlocking the Link: Nutritional Deficiency and Blood Barrier Dysfunction in Aging Eye and Brain, Unveiling the Role of TRP Channels, Ca+2 Influx, and Stress Pathways	Hevolution Foundation, Riyadh, Saudi Arabia, 2025