- الرئيسية
- عن الجامعة
- نهال محسن احمد الشربينى
نهال محسن احمد الشربينى
أستاذ الكيمياء الحيوية الصيدلية
محكّم لأكثر من 100 مجلة علمية مفهرسة في Scopus وISI.
محرر مشارك في Frontiers in Endocrinology.
رئيس/ضيف محرر لعدد خاص في Journal of Diabetes Research وFrontiers in Endocrinology.
محكّم لأكثر من 100 مجلة علمية مفهرسة في Scopus وISI.
محرر مشارك في Frontiers in Endocrinology.
رئيس/ضيف محرر لعدد خاص في Journal of Diabetes Research وFrontiers in Endocrinology.
السيرة الذاتية
جدول الدراسة
الابحاث والمؤلفات
المشاريع البحثية
الجوائز
الخبرات والمناصب الإدارية
- منسقة الشؤون الأكاديمية – شطر الطالبات.
- عضو في وحدة الأنشطة الطلابية.
- مشرفة قسم الكيمياء الصيدلية – شطر الطالبات.
- عضو في وحدة الإبداع والموهبة.
- رئيس وحدة خدمة المجتمع – كلية الصيدلة.
- عضو في وحدة الجودة والاعتماد الأكاديمي.
المؤهلات العلمية
- 05/2013: دكتوراه في العلوم الصيدلية (الكيمياء الحيوية)، كلية الصيدلة، جامعة المنصورة، مصر (بإشراف مشترك مع Georgia Regents University، ولاية جورجيا، الولايات المتحدة الأمريكية).
عنوان رسالة الدكتوراه:
"دراسة تأثير مستقبلات الأدينوزين والإنزيمات المسؤولة عن أيض الأدينوزين في القوارض المصابة بمضاعفات داء السكري." - 05/2010: درجة الماجستير في العلوم الصيدلية (الكيمياء الحيوية)، كلية الصيدلة، جامعة المنصورة، مصر.
عنوان رسالة الماجستير:
"دراسة بيوكيميائية لبعض البروتينات السكرية والإنزيمات المسؤولة عن تحللها لدى مرضى سرطان الخلايا الكبدية." - 07/2007: بكالوريوس الصيدلة، بتقدير ممتاز مع مرتبة الشرف، كلية الصيدلة، Mansoura University، المنصورة، مصر.
الاهتمامات البحثية
استهداف الآليات الجزيئية المرضية الكامنة وراء الأمراض الشائعة في منطقة تبوك، مثل السرطان وداء السكري.
تقييم التأثيرات العلاجية والوقائية المحتملة للاستراتيجيات الحديثة، مثل الخلايا الجذعية والإكسوسومات والأدوية المصاغة بتقنية النانو، في علاج الأمراض الشائعة في منطقة تبوك.
دراسة وتقييم الأدوية المعتمدة حاليًا لاكتشاف استخدامات علاجية جديدة لها (إعادة توظيف الأدوية - Drug Repurposing
| اليوم | المادة | الوقت |
|---|---|---|
| الأحد | --- | 15:00 - 17:00 |
?-Lipoic Acid Protects against Cyclosporine A-Induced Hepatic Toxicity in Rats: Effect on Oxidative Stress, Inflammation, and Apoptosis
Toxics
DOI
10.3390/toxics10080442
Adipose mesenchymal stem cells combined with platelet-rich plasma accelerate diabetic wound healing by modulating the Notch pathway
Stem Cell Research & Therapy
DOI
10.1186/s13287-021-02454-y
Anti-inflammatory/anti-apoptotic impact of betulin attenuates experimentally induced ulcerative colitis: An insight into tlr4/nf-kb/caspase signalling modulation
Environmental Toxicology and Pharmacology
DOI
10.1016/j.etap.2021.103750
Astrocytes profiling in acute hepatic encephalopathy: Possible enrolling of glial fibrillary acidic protein, tumor necrosis factor-alpha, inwardly rectifying potassium channel …
Frontiers in Cellular Neuroscience
DOI
10.3389/fncel.2022.896172
Atorvastatin Ameliorates Cerebral Cortical Pathological and Cognitive Alterations in Aged Rats: Histological & Immunohistochemical Study
TISSUE & CELL
DOI
10.1016/j.tice.2025.103184
CRISPR/Cas9 System as a Promising Therapy in Thalassemia and Sickle Cell Disease: A Systematic Review of Clinical Trials
MOLECULAR BIOTECHNOLOGY
DOI
10.1007/s12033-025-01368-x
Canagliflozin Reduce la Respuesta Contr?ctil del Coraz?n Aislado de Ratas Adultas Normales
INTERNATIONAL JOURNAL OF MORPHOLOGY
DOI
10.4067/s0717-95022022000501300
Chitosan-coated nanoemulsion for the direct nose-to-brain delivery of sildenafil: development and in vivo evaluation in a brain oxidative stress and inflammation model
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
DOI
10.1016/j.jddst.2024.105842
Curcumin Modulates Oxidative Stress, Fibrosis, and Apoptosis in Drug-Resistant Cancer Cell Lines
Life-Basel
DOI
10.3390/life12091427
Curcumin-loaded gold nanoparticles with enhanced antibacterial efficacy and wound healing properties in diabetic rats
INTERNATIONAL JOURNAL OF PHARMACEUTICS
DOI
10.1016/j.ijpharm.2024.124761
Dapagliflozin, Liraglutide, and Their Combination Attenuate Diabetes Mellitus-Associated Hepato-Renal Injury—Insight into Oxidative Injury/Inflammation/Apoptosis Modulation
Life-Basel
DOI
10.3390/life12050764
Decoding Diabetes Biomarkers and Related Molecular Mechanisms by Using Machine Learning, Text Mining, and Gene Expression Analysis
International Journal of Environmental Research and Public Health
DOI
10.3390/ijerph192113890
Design, synthesis and pharmacological screening of novel renoprotective methionine-based peptidomimetics: amelioration of cisplatin-induced nephrotoxicity
BIOORGANIC CHEMISTRY
DOI
10.1016/j.bioorg.2021.105100
Development and evaluation of fusidic acid myrrh oil organogel for the reversal of Gram-negative bacterial resistance and improvement of wound-healing potential
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
DOI
10.1016/j.jddst.2025.107247
Development and optimization of flaxseed oil nanoemulsions: implications for ulcerative colitis treatment
JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY
DOI
10.1080/01932691.2025.2456530
Development, optimization, and assessment of losartan nano-bilosomes to mitigate diabetes-induced microvascular complications in Sprague Dawley rats
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
DOI
10.1016/j.jddst.2023.105295
Diacerein ameliorates testosterone-induced benign prostatic hyperplasia in rats: Effect on oxidative stress, inflammation and apoptosis
International Immunopharmacology
DOI
10.1016/j.intimp.2021.108082
Diacerein attenuates 1, 2?dimethylhydrazine induced colon cancer progression in rats: Modulation of IL?6/STAT3/lncRNA HOTAIR pathway
FASEB JOURNAL
DOI
10.1096/fasebj.2022.36.s1.r3035
Diacerein's Antiproliferative Effects Alone and with 5-Fluorouracil in an Ehrlich Solid Tumour Model: Molecular Docking, Molecular Dynamics Simulation Studies, and Experimental …
European Journal of Pharmacology
DOI
10.1016/j.ejphar.2025.177564
Effect of Diacerein on HOTAIR/IL-6/STAT3, Wnt/?-Catenin and TLR-4/NF-?B/TNF-? axes in colon carcinogenesis
Environmental Toxicology and Pharmacology
DOI
10.1016/j.etap.2022.103943
Effect of bone marrow mesenchymal stem cells-derived exosomes on diabetes-induced retinal injury: Implication of Wnt/b-catenin signaling pathway
BIOMEDICINE & PHARMACOTHERAPY
DOI
10.1016/j.biopha.2022.113554
Enhanced skin permeation and controlled release of ?-sitosterol using cubosomes encrusted with dissolving microneedles for the management of alopecia
Pharmaceuticals
DOI
10.3390/ph16040563
Exercise augments the effect of SGLT2 inhibitor dapagliflozin on experimentally induced diabetic cardiomyopathy, possible underlying mechanisms
Metabolites
DOI
10.3390/metabo12070635
Exosomes in COVID?19 infection: Focus on role in diagnosis, pathogenesis, immunity, and clinical trials
CELL BIOLOGY INTERNATIONAL
DOI
10.1002/cbin.12014
Exosomes: Isolation, characterization, and biomedical applications
CELL BIOLOGY INTERNATIONAL
DOI
10.1002/cbin.11620
Exploring the role of Müller cells-derived exosomes in diabetic retinopathy
MICROVASCULAR RESEARCH
DOI
10.1016/j.mvr.2024.104695
Formulation and characterization of cholesterol-based nanoparticles of gabapentin protecting from retinal injury
Frontiers in Chemistry
DOI
10.3389/fchem.2024.1449380
Functional recellularization of acellular rat liver scaffold by induced pluripotent stem cells: Molecular evidence for wnt/b-catenin upregulation
Cells
DOI
10.3390/cells10112819
Ginger oil nanoemulsion formulation augments its antiproliferative effect in ehrlich solid tumor model
Foods
DOI
10.3390/foods12224139
Insights in renal endocrinology: 2021
Frontiers in Endocrinology
DOI
10.3389/fendo.2022.1003683
Isoliquiritigenin attenuates inflammation and modulates Nrf2/caspase-3 signalling in STZ-induced aortic injury
JOURNAL OF PHARMACY AND PHARMACOLOGY
DOI
10.1093/jpp/rgaa056
Lyophilized MSC-EVs attenuates COVID-19 pathogenesis by regulating the JAK/STAT pathway
Stem Cell Research & Therapy
DOI
10.1186/s13287-025-04284-8
MSCs–derived EVs protect against chemotherapy-induced ovarian toxicity: role of PI3K/AKT/mTOR axis
Journal of Ovarian Research
DOI
10.1186/s13048-024-01545-7
Maxillary mucormycosis osteomyelitis in post COVID-19 patients: a series of fourteen cases
Diagnostics
DOI
10.3390/diagnostics11112050
Microneedle mediated transdermal delivery of ?-sitosterol loaded nanostructured lipid nanoparticles for androgenic alopecia
DRUG DELIVERY
DOI
10.1080/10717544.2022.2120927
Multilineage Differentiating Stress Enduring (Muse) Cells: A New Era of Stem Cell-Based Therapy
Cells
DOI
10.3390/cells12131676
Nanogold Particles Suppresses 5-Flurouracil-Induced Renal Injury: An Insight into the Modulation of Nrf-2 and Its Downstream Targets, HO-1 and ?-GCS
MOLECULES
DOI
10.3390/molecules26247684
Neuroprotective effect of morin hydrate against attention-deficit/hyperactivity disorder (ADHD) induced by MSG and/or protein malnutrition in rat pups: Effect on oxidative …
Pharmaceuticals
DOI
10.3390/ph15081012
Nifuroxazide repurposing for protection from diabetes?induced retinal injury in rats: Implication of oxidative stress and JAK/STAT3 axis
BIOFACTORS
DOI
10.1002/biof.2011
Optimization and In Vitro Characterization of Telmisartan Loaded Sodium Alginate Beads and Its In Vivo Efficacy Investigation in Hypertensive Induced Animal Model
Pharmaceutics
DOI
10.3390/pharmaceutics15020709
Optimized Nanostructured Lipid Carriers for Metformin: Enhanced Anti-Inflammatory Activity and Protection Against Type 2 Diabetes-Induced Organ Damage
International Journal of Nanomedicine
DOI
10.2147/ijn.s506631
Origanum majorana L. Extract Attenuated Benign Prostatic Hyperplasia in Rat Model: Effect on Oxidative Stress, Apoptosis, and Proliferation
Antioxidants
DOI
10.3390/antiox11061149
P-glycoproteins in the Pathology and Treatment of Alzheimer's Disease
Letters in Drug Design & Discovery
DOI
10.2174/0115701808293022240216070603
Polycaprolactone nanocapsule-loaded carbopol hydrogel enhances fusidic acid efficacy against Gram-negative bacteria and promotes wound healing
INTERNATIONAL JOURNAL OF PHARMACEUTICS
DOI
10.1016/j.ijpharm.2025.125735
Possible cytotoxic effect of allantoin on oral squamous cell carcinoma stemness (in vivo and in vitro model
FASEB JOURNAL
DOI
10.1096/fasebj.2022.36.s1.r3123
Pramipexole protects against diabetic neuropathy: Effect on oxidative stress, TLR4/IRAK-1/TRAF-6/NF-?B and downstream inflammatory mediators
International Immunopharmacology
DOI
10.1016/j.intimp.2024.111514
Preparation and characterization of novel polyelectrolyte liposomes using chitosan succinate layered over Chitosomes: a potential strategy for colon cancer treatment
Biomedicines
DOI
10.3390/biomedicines12010126
Prophylactic evidence of MSCs-derived exosomes in doxorubicin/trastuzumab-induced cardiotoxicity: beyond mechanistic target of NRG-1/Erb signaling pathway
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
DOI
10.3390/ijms23115967
Punicalagin’s protective effects on Parkinson’s progression in socially isolated and socialized rats: insights into multifaceted pathway
Pharmaceutics
DOI
10.3390/pharmaceutics15102420
Revised title: Design, synthesis, and biological evaluation of Benzimidazole–Aminopyrimidine hybrids as selective P38? MAPK inhibitors targeting Neuroinflammation in an AlCl3-induced rat model of Alzheimer's disease
BIOORGANIC CHEMISTRY
DOI
10.1016/j.bioorg.2025.109391
Role of dapagliflozin and liraglutide on diabetes-induced cardiomyopathy in rats: implication of oxidative stress, inflammation, and apoptosis
Frontiers in Endocrinology
DOI
10.3389/fendo.2022.862394
The Combined Anti-Tumor Efficacy of Bioactive Hydroxyapatite Nanoparticles Loaded with Altretamine
Pharmaceutics
DOI
10.3390/pharmaceutics15010302
The Implication of Mechanistic Approaches and the Role of the Microbiome in Polycystic Ovary Syndrome (PCOS): A Review
Metabolites
DOI
10.3390/metabo13010129
The Possible Mechanisms of Cu and Zn in the Treatment and Prevention of HIV and COVID-19 Viral Infection
BIOLOGICAL TRACE ELEMENT RESEARCH
DOI
10.1007/s12011-023-03788-9
Vitamin K2 (MK-7) intercepts Keap-1/Nrf-2/HO-1 pathway and hinders inflammatory/apoptotic signaling and liver aging in naturally aging rat
Antioxidants
DOI
10.3390/antiox11112150
Vitamin K2 (MK?7) modulated Nrf2/NLRP3/caspase?1 axis to protect against age?related structural and cognitive deterioration in naturally aged rats
FASEB JOURNAL
DOI
10.1096/fasebj.2022.36.s1.r3319
Vitamin K2 (Menaquinone-7) Reverses Age-Related Structural and Cognitive Deterioration in Naturally Aging Rats
Antioxidants
DOI
10.3390/antiox11030514
Optimization and evaluation of Olmesartan medoxomil spanlastics for the management of epilepsy
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
DOI
10.1016/j.jddst.2026.108487
| اسم المشروع | وصف المشروع |
|---|---|
| Possible cytotoxic effect of allantoin on oral squamous cell carcinoma stemness (in vivo and in vitro model) | Funded by Research unit, AlMaarefa University, Riyadh, Saudi Arabia |
| Targeting IL-6/STAT3/ lncRNA HOTAIR axis for treatment of colorectal cancer | Funded by Research unit, AlMaarefa University, Riyadh, Saudi Arabia |
| Novel Strategy for Alleviating Diabetic Complications: Targeting Sirt-1 for renal, retinal and arterial injury | Funded by Deanship of Scientific Research, University of Tabuk, Tabuk, Saudi Arabia |
| Development of new strategies for treatment of breast cancer: Implication of Notch signaling | Funded by Deanship of Scientific Research, University of Tabuk, Tabuk, Saudi Arabia |
| Neuroprotective effect of donepezil against diabetic retinopathy and optic nerve damage: possible downregulation of glutamate receptors and modulation of AMPK/mTOR pathway | Funded by Deanship of Scientific Research, University of Tabuk, Tabuk, Saudi Arabia |
| Effect of Calycocin on Diabetic Nephropathy: Implication of IL-33/ST2 Signaling Pathway | Funded by Deanship of Scientific Research, University of Tabuk, Tabuk, Saudi Arabia |
| Role of Valproate sodium in alloxan diabetic mice: influence on spinal histone deacetylase inhibition and glia reactivity | Funded by Deanship of Scientific Research, University of Tabuk, Tabuk, Saudi Arabia |
| Study of the reno-protective effect of nifuroxazide in diabetic nephropathy | Funded by Deanship of Scientific Research, University of Tabuk, Tabuk, Saudi Arabia |
| Protective effect of Caffeic acid phenethyl ester against rotenone-induced neurodegeneration: implication for Parkinson’s disease therapy | Funded by Deanship of Scientific Research, University of Tabuk, Tabuk, Saudi Arabia |
| Control of heparin Sulfate Proteoglycans degradation: New therapy for Hepatocellular Carcinoma | Funded by Mansoura University, Mansoura, Egypt |
| Design and development of polymer coated microneedle-mediated delivery of β-sitosterol for the treatment of androgenic alopecia | Funded by Ministry of High Education, Saudi Arabia |
| Sleep Deprivation-Induced Brain Deficits in Naturally Aged Rats and Role of Oxytocin: Behavioral, Cognitive, And Molecular Evidence | Hevolution Foundation, Riyadh, Saudi Arabia, 2023 |
| Unlocking the Link: Nutritional Deficiency and Blood Barrier Dysfunction in Aging Eye and Brain, Unveiling the Role of TRP Channels, Ca+2 Influx, and Stress Pathways | Hevolution Foundation, Riyadh, Saudi Arabia, 2025 |
- الحصول على منحة الحكومة المصرية لنيل درجة الدكتوراه بالتعاون مع كلية الطب بولاية جورجيا، الولايات المتحدة الأمريكية، بنظام الإشراف المشترك.
- الحصول على منحة الحكومة المصرية للتدريب ما بعد الدكتوراه في جامعة جورجيا ريجنتس، الولايات المتحدة الأمريكية.
- جائزة التميز (أفضل عضو هيئة تدريس)، University of Tabuk، تبوك، المملكة العربية السعودية، عام 2019.
- المركز الأول لأفضل ملصق بحثي (Poster) بعنوان:
"Calycosin suppressed inflammation in diabetes-induced renal injury: potential role of IL-33 signaling pathway"
وذلك خلال المؤتمر العلمي التاسع لإدارة الرعاية الصيدلية بتبوك الصحية تحت عنوان الأمراض الالتهابية المناعية، المنعقد خلال الفترة 10–11 أبريل 2019، تبوك، المملكة العربية السعودية. - المركز السابع لأفضل ملصق طلابي بعنوان:
"Umbilical Cord Stem Cells: Background, Processing and Applications"
خلال معرض ومؤتمر Dubai Pharmaceutical & Technologies Exhibition (DUPHAT)، المنعقد في دبي، الإمارات العربية المتحدة، خلال الفترة 25–27 فبراير 2020. - جائزة الدولة التشجيعية في العلوم الطبية لعام 2020، المقدمة من وزارة التعليم العالي والبحث العلمي المصرية، وهي جائزة تُمنح لأفضل سبعة علماء في مجال العلوم الطبية بالجامعات المصرية ممن تقل أعمارهم عن 40 عامًا، استنادًا إلى إنتاجهم ونشاطهم العلمي المتميز.
- المركز الأول لأفضل ملصق بحثي طلابي في العلوم الصيدلية خلال المؤتمر وورش العمل الصيدلانية الدولية السعودية (SIPHA)، المنعقد في الدمام، المملكة العربية السعودية، خلال الفترة 3–5 يناير 2023.
- المركز الثاني – جائزة أفضل ملصق طلابي معروض خلال مؤتمر ومعرض DUPHAT 2025.
- المركز الثاني – جائزة أفضل ملصق طلابي ابتكاري خلال مؤتمر ومعرض DUPHAT 2025.
الكلية
كلية الصيدلة
التخصص العام
الكيمياء الصيدلية
التخصص الدقيق
الكيمياء الحيوية
الدرجة العلمية (المرتبة)
دكتوراه
الجنسية
المصرية
المسمى الوظيفي
استاذ مشارك