محمد محمد حلمي عبد الرحمن الجيار

View my profile on: Google Scholar http://scholargooglecom/citations?user=UP77ZW8AAAAJ Researchgate https://wwwresearchgatenet/profile/Mohammed_Al-Gayyar/ ResearcherID E-8250-2014 Scopus Author ID 16244368100 Orcid http://orcidorg/0000-0003-4777-3919

السيرة الذاتية

جدول الدراسة

الابحاث والمؤلفات

المشاريع البحثية

الجوائز

اليوم	المادة	الوقت
الأحد	Office hours	09:00 - 12:00
الأحد	Clinical Biochemistry Lecture	13:00 - 15:00
الإثنين	Academic Advising	10:00 - 12:00
الإثنين	Clinical Biochemistry Training	13:00 - 15:00
الثلاثاء	Office hours	09:00 - 12:00
الخميس	Office hours	10:00 - 12:00

Al-Gayyar MM, Eissa LA, Rabie AM, El-Gayar AM (2007): Measurements of oxidative stress status and antioxidant activity in chronic leukaemia patients J Pharm Pharmacol 59(3):409-17 (Impact factor=1718)
El-Mesery M, Al-Gayyar M, Salem H, Darweish M, El-Mowafy A (2009): Chemopreventive and renal protective effects for docosahexaenoic acid (DHA): implications of CRP and lipid peroxides Cell Div, 4:6 (Impact factor=36)
El-Mowafy AM, El-Mesery ME, Salem HA, Al-Gayyar MM, Darweish MM (2010): Prominent Chemopreventive and Chemoenhancing Effects for Resveratrol: Unraveling Molecular Targets and the Role of C-Reactive Protein Chemotherapy, 56(1):60-65 (Impact factor=2108)
Al-Gayyar MM, Abdelsaid MA, Matragoon S, Pillai BA, El-Remessy AB (2010): Neurovascular protective effect of FeTPPs in N-methyl-D-aspartate model: similarities to diabetes Am J Pathol, 177(3):1187-97 (Impact factor=604)
El-Mowafy AM, Al-Gayyar MM, Salem HA, El-Mesery ME, Darweish MM (2010): Novel chemotherapeutic and renal protective effects for the green tea (EGCG): role of oxidative stress and inflammatory-cytokine signaling Phytomedicine, 17(14):1067-75 (Impact factor=2662)
Whitmire W, Al-Gayyar MM, Abdelsaid M, Yousufzai BK, El-Remessy AB (2011): Alteration of Growth Factors and Neuronal Death in Diabetic Retinopathy: What We Have Learned So Far Mol Vis, 2817:300-8 (Impact factor=2541)
Ali TK, Al-Gayyar MM, Matragoon S, Pillai BA, Abdelsaid MA, Nussbaum JJ, El-Remessy AB (2011): Diabetes-induced peroxynitrite impairs the balance of pro-nerve growth factor and nerve growth factor, and causes neurovascular injury Diabetologia, 54(3):657-68 (Impact factor=6973)
Al-Gayyar MM, Matragoon S, Pillai BA, Ali TK, Abdelsaid MA, El-Remessy AB (2011): Epicatechin blocks pro-nerve growth factor (proNGF)-mediated retinal neurodegeneration via inhibition of p75 neurotrophin receptor expression in a rat model of diabetes Diabetologia, 54(3):669-80 (Impact factor=6973)
El-Mowafy AM, Salem HA, Al-Gayyar MM, El-Mesery ME, El-Azab MF (2011): Evaluation of renal protective effects of the green-tea (EGCG) and red grape resveratrol: role of oxidative stress and inflammatory cytokines Nat Prod Res, 25(8):850-6 (Impact factor=081)
Ibrahim AS, El-Remessy AB, Matragoon S, Zhang W, Patel Y, Khan S, Al-Gayyar MM, El-Shishtawy MM, Liou GI (2011): Retinal Microglial Activation and Inflammation Induced by Amadori-Glycated Albumin in a Rat Model of Diabetes Diabetes, 60(4):1122-33 (Impact factor=8505)
El-Remessy AB, Rajesh M, Mukhopadhyay P, Horváth B, Patel V, Al-Gayyar MM, Pillai BA, Pacher P (2011): Cannabinoid 1 receptor activation contributes to the vascular inflammation and cell death in diabetic retinopathy Diabetologia, 54(6):1567-78 (Impact factor=6973)
Hassan HM, El-Gayar AM, Ibrahim TM, Al-Gayyar MMH (2011): Anti-inflammatory Effect of Simvastatin-Aspirin Combination International Journal of Pharmaceutical Sciences and Drug Research, 3(2): 89-96
Al-Gayyar MM, Abdelsaid MA, Matragoon S, Pillai BA, El-Remessy AB (2011): Thioredoxin Interacting Protein Is a Novel Mediator of Retinal Inflammation and Neurotoxicity Br J Pharmacol, 164(1):170-80 (Impact factor=5204)
Shams ME, Al-Gayyar MM, Barakat EA (2011): Type 2 Diabetes Mellitus-Induced Hyperglycemia in Patients with NAFLD and Normal LFTs: Relationship to Lipid Profile, Oxidative Stress and Pro-Inflammatory Cytokines Sci Pharm, 79(3):623–34 (Impact factor=0853)
Shams ME, Al-Gayyar MM, Barakat EA, Ebrahim MA, El-Shishtawy MM (2011): Circulating adiponectin: a potential prognostic marker for hepatocellular carcinoma Chin Ger J Clin Oncol, 10(10):570-4
Al-Gayyar MM, Shams ME, Barakat EA (2012): Fish oil improves lipid metabolism and ameliorates inflammation in patients with metabolic syndrome: Impact of nonalcoholic fatty liver disease Pharm Biol, 50(3):297-303 (Impact factor=1337)
Metwaly HA, Al-Gayyar MM, Eletreby S, Ebrahim MA, El-Shishtawy MM (2012): Relevance of Serum Levels of Interleukine-6 and Syndecan-1 in Patients with Hepatocellular Carcinoma Sci Pharm, 80(1):179-188 (Impact factor=1088)
Elsherbiny NM, Abd El Galil KH, Gabr MM, Al-Gayyar MM, Eissa LA, El-Shishtawy MM (2012): Reno-protective effect of NECA in diabetic nephropathy: Implication of IL-18 and ICAM-1 Eur Cytokine Netw, 23(3):78-86 (Impact factor=1960)
Matragoon S, Al-Gayyar MM, Mysona BA, Abdelsaid MA, Pillai BA, Fagan SC, El-Remessy AB (2012): Electroporation-mediated gene delivery of cleavage-resistant pro-Nerve Growth Factor Causes retinal neuro- and vascular degeneration Mol Vis, 18:2993-3003 (Impact factor=221)
Awad MA, Shams ME, Al-Gayyar MM, El-Shishtawy MM (2012): Circulating Adiponectin in Hepatocellular Carcinoma: A Possible Risk Factor for Development and Progression Eur J Clin Med Oncol 4:4
Al-Gayyar MM, Mysona BA, Matragoon S, Abdelsaid MA, El-Azab MF, Shanab AY, Ha Y, Smith SB, Bollinger KE, El-Remessy AB (2013): Diabetes and overexpression of proNGF cause retinal neurodegeneration via activation of RhoA pathway PLoS One, 8(1):e54692 (Impact factor=3534)
Al-Gayyar MM, Elsherbiny NM (2013): Contribution of TNF-α to development of retinal neurodegenerative disorders Eur Cytokine Netw, 24(1):27-36 (Impact factor=1960)
Elsherbiny NM, Al-Gayyar MM (2013): Adenosine Receptors: New Therapeutic Targets for Inflammation in Diabetic Nephropathy Inflamm Allergy Drug Targets, 12(3):153-61 (Impact factor=269)
Elsherbiny NM, Naime M, Ahmad S, Elsherbini AM, Mohammad S, Fulzele S, El-Remessy AB, Al-Gayyar MM, Eissa LA, El-Shishtawy MM, Han G, White R, Haroldo TF, Liou GI (2013): Potential roles of adenosine deaminase-2 in diabetic retinopathy Biochem Biophys Res Commun, 436(3):355-61 (Impact factor=2484)
Elsherbiny NM, Ahmad S, Naime M, Elsherbini AM, Fulzele S, Al-Gayyar MM, Eissa LA, El-Shishtawy MM, Liou GI (2013): ABT-702, an Adenosine Kinase Inhibitor, Attenuates Inflammation in Diabetic Retinopathy Life Science, 93(2-3):78-88 (Impact factor=2296)
Al-Gayyar MM, Awad MA, Shams ME (2013): Measuring Serum Levels of Glycosaminoglycans for Prediction and Using Viscum Fraxini-2 for Treatment of Patients with Hepatocellular Carcinoma J Pharm Res, 7(7):571-5
Mysona BA, Al-Gayyar MM, Matragoon S, Abdelsaid MA, El-Azab M, Saragovi HU, El-Remessy AB (2013): Modulating p75NTR prevents diabetes- and proNGF-induced retinal inflammation and blood retina barrier breakdown Diabetologia, 56(10):2329-39 (Impact factor=6880)
Salama MF, Abbas A, Darweish MM, El-Hawwary AA, Al-Gayyar MM (2013): Hepatoprotective effects of cod liver oil against sodium nitrite toxicity in rats Pharm Biol, 51(11):1435-43 (Impact factor=1337)
Sherif IO, Al-Gayyar MM (2013): Antioxidant, Anti-inflammatory and Hepatoprotective Effects of Silymarin against Hepatic Dysfunction Induced by Sodium Nitrite Eur Cytokine Netw, 24(3):114-21 (Impact factor=1960)
Zaghloul RA, Al-Gayyar MM, El-Shishtawy MM, Ebrahim MA (2013): Cytotoxic effects of antiglypican-3 against HepG2 cell lines J App Pharm Sci, 3(12):31-5
Bayomi HS, Elsherbiny NM, El-Gayar AM, Al-Gayyar MM (2013): Evaluation of Renal Protective Effects of Inhibiting TGF-β Type I Receptor in Cisplatin-Induced Nephrotoxicity Model Eur Cytokine Netw, 24(4):139-47 (Impact factor=1960)
Hassan HM, Al-Gayyar MM, El-Gayar AM, Ibrahim TM (2014): Effect of simvastatin on inflammatory cytokines balance in air pouch granuloma model Inflamm Allergy Drug Targets, 13(1):74-9 (Impact factor=269)
Tayel A, Abd El Galil KH, Ebrahim MA, Ibrahim AS, El-Gayar AM, Al-Gayyar MM (2014): Suramin inhibits hepatic tissue damage in hepatocellular carcinoma through deactivation of heparanase enzyme Eur J Pharmacol, 728C:151-60 (Impact factor=2684)
Darweish MM, Abbas A, Ebrahim MA, Al-Gayyar MM (2014): Chemopreventive and Hepatoprotective Effects of EGCG against Hepatocellular Carcinoma: Role of Heparan Sulfate Proteoglycans Pathway J Pharm Pharmacol, 66(7):1032-45 (Impact factor=2161)
Al-Gayyar MM, Al Youssef A, Sherif IO, Shams ME, Abbas A (2014): Protective effects of arjunolic acid against cardiac toxicity induced by oral sodium nitrite: effect on cytokines balance and apoptosis Life Sci, 111(1-2):18-26 (Impact factor=2702)
Tayel T, Ebrahim MA, Ibrahim AS, El-Gayar AM, Al-Gayyar MM (2014): Cytotoxic effects of Suramin against HepG2 cells through activation of intrinsic apoptotic pathway JBUON, 19(4):1048-54 (Impact factor=0706)
Hamdan AM, Al-Gayyar MM, Alyoussef A (2014): Establishing and Validation of Modified CRE/Loxp System Useful In Temporal and Spatial Control of Genetic Knocking Out Using In Vitro Approaches by Induced Alpha Complementation Clin Res Dev Open Access, 1(2):109 http://dxdoiorg/1014437/CRDOA-1-109
Al-Gayyar MM, Alyoussef A, Hamdan AM, Abbas A, Darweish MM, El-Hawwary AA (2015): Cod liver oil ameliorates sodium nitrite induced insulin resistance and degradation of rat hepatic glycogen through inhibition of cAMP/PKA pathway Life Sci, 120:13-21 (Impact factor=2702)
Zaghloul RA, El-Shishtawy MM, Abd El Galil KH, Ebrahim MA, Metwaly AA, Al-Gayyar MM (2015): Evaluation of antiglypican-3 therapy as a promising target for amelioration of hepatic tissue damage in hepatocellular carcinoma Eur J Pharmacol, 746:353–362 (Impact factor=2684)
Sherif IO, Al-Gayyar MM (2015): Cod liver oil in sodium nitrite induced hepatic injury: Does it have a potential protective effect? Redox Rep, 20(1):11-6 (Impact factor=1710)
Elewa MA, Al-Gayyar MM, Schaalan MF, El-Shishtawy MM (2015) Antitumor activity of doxycycline in HepG-2 cells International Journal of Advanced Research, 3(1):834-46
Elewa MA, Al-Gayyar MM, Schaalan MF, Abd El Galil KH, Ebrahim MA, El-Shistawy MM (2015): Hepatoprotective and anti-tumor effects of targeting MMP-9 in hepatocellular carcinoma and its relation to vascular invasion markers Clin Exp Metastasis, 32(5):479-93 (Impact factor = 3725)
Al-Gayyar MM, Alyoussef A (2015): Oral sodium nitrite enhanced oxidative stress and inflammatory cytokines levels in testicular tissue Clin Res Dev Open Access, 2(1):111 http://dxdoiorg/1014437/CRDOA-2-111
El Kramani N, Elsherbiny NM, El-Gayar AM, Ebrahim MA, Al-Gayyar MM (2015): Evaluation of leukocytes tumor necrosis factor receptor 2 in acute leukemia patients Clin Res Dev Open Access 2(2):115 http://dxdoiorg/1014437/2378-7708-2-115
Elsherbiny NM, Al-Gayyar MM, Abd El Galil KH (2015): Nephroprotective role of dipyridamole in diabetic nephropathy: Effect on inflammation and apoptosis Life Sci, 143:8–17 (Impact factor=2702)
El Kramani N, Elsherbiny NM, El-Gayar AM, Ebrahim MA, Al-Gayyar MMH (2015): Tumor necrosis factor receptor 2: Its clinical significance and clinicopathologic correlation in acute leukemias J App Pharm Sci, 5 (11):079-083
Elsherbiny NM, Eladl MA, Al-Gayyar MM (2016): Renal protective effects of arjunolic acid in a Cisplatin-induced nephrotoxicity model Cytokine, 77(1):26-34 (Impact factor=2717)
Elsherbiny NM, Al-Gayyar MM (2016): The Role of IL-18 in Type 1 Diabetic Nephropathy: The problem and future treatment Cytokine, 81:15-22 (Impact factor=2717)
Elsherbiny NM, Salama MF, Said E, El-Sherbiny M, Al-Gayyar MM (2016): Crocin protects against Doxorubicin-induced myocardial toxicity in rats through downregulation of inflammatory and apoptic pathways Chem Biol Interact, 247:39–48 (Impact factor=2817)
Al-Gayyar MM, Abbas A, Hamdan AM (2016): Chemopreventive and Hepatoprotective Roles of Adiponectin (SULF2 inhibitor) in Hepatocelluar Carcinoma (HCC) Biol Chem, 397(3):257-67 (Impact factor=3268)
Alyoussef A, Al-Gayyar MM (2016): Thymoquinone ameliorated elevated inflammatory cytokines in testicular tissue and sex hormones imbalance induced by oral chronic toxicity with sodium nitrite Cytokine, 83:64-74 (Impact factor=2717)
Al-Gayyar MM, Hassan HM, Alyoussef A, Abbas A, Darweish MM, El-Hawwary AA (2016): Nigella sativa oil attenuates chronic nephrotoxicity induced by oral sodium nitrite: Effects on tissue fibrosis and apoptosis Redox Rep, 21(2):50-60 (Impact factor=1710)
Elsherbiny NM, Al-Gayyar MM (2016): Anti-tumor activity of arjunolic acid against Ehrlich Ascites Carcinoma cells in vivo and in vitro through blocking TGF-b type 1 receptor Biomed Pharmacother, 82 (2016) 28–34 (Impact factor=208)
Alyoussef A, Al-Gayyar MM (2016): Thymoquinone ameliorates testicular tissue inflammation induced by chronic administration of oral sodium nitrite Andrologia, 48(5):501-8 (Impact factor=163)
Arffa ML, Zapf MA, Kothari AN, Chang V, Gupta GN, Ding X, Al-Gayyar MM, Syn W, Elsherbiny NM, Kuo PC, Mi Z (2016): Epigallocatechin-3-Gallate Upregulates miR-221 to Inhibit Osteopontin-Dependent Hepatic Fibrosis PLoS One, 11(12):e0167435 (Impact factor=3057)
Elsherbiny NM, Maysarah NM, El-Sherbiny M, Al-Gayyar MM (2017): Renal protective effects of thymoquinone against sodium nitrite-induced chronic toxicity in rats: Impact on inflammation and apoptosis Life Sci, 180:1-8 (Impact factor=3234)
Al-Gayyar MM, Sherif IO (2018): Oleuropein potentiates anti-tumor activity of cisplatin against HepG2 through affecting proNGF/NGF balance Life Sci, 198:87-93 (Impact factor=3448)
Alyoussef A, Al-Gayyar MMH (2018): Cytotoxic and partial hepatoprotective activity of sodium ascorbate against hepatocellular carcinoma through inhibition of sulfatase-2 in vivo and in vitro Biomed Pharmacother, 103:362-372 (Impact factor=3743)
El Kramani N, Elsherbiny NM, El-Gayar AM, Ebrahim MA, Al-Gayyar MMH (2018): Clinical significance of the TNF-α receptors, TNFRSF2 and TNFRSF9, on cell migration molecules Fascin-1 and Versican in acute leukemia Cytokine, 111:523-9 (Impact factor=3078)
Al-Gayyar MMH, Bagalagel A, Noor AO, Almasri DM, Diri R (2019): The therapeutic effects of nicotinamide in hepatocellular carcinoma through blocking IGF-1 and effecting the balance between Nrf2 and PKB Biomed Pharmacother, 112:108653 (Impact factor=4545)
Hamdan AM, Al-Gayyar MM, Shams MEE, Alshaman US, Prabahar K, Bagalagel A, Diri R, Noor AO, Almasri D (2019): Thymoquinone therapy remediates elevated brain tissue infammatory mediators induced by chronic administration of food preservatives Sci Rep, 9(1):7026 (Impact factor=3998)
Nazmy EA, El-Khouly OA, Zaki MM, Elsherbiny NM, Said E, Al-Gayyar MMH, Salem HA (2019): Targeting p53/TRAIL/caspase-8 signaling by adiponectin reverses thioacetamide-induced hepatocellular carcinoma in rats Environ Toxicol Pharmacol, 72:103240 (Impact factor=3292)
El-Far YM, Khodir AE, Noor AO, Almasri DM, Bagalagel AA, Diri RM, Kutbi HI, Al-Gayyar MM (2020): Selective cytotoxic activity and protective effects of sodium ascorbate against hepatocellular carcinoma through its effect on oxidative stress and apoptosis in vivo and in vitro Redox Rep, 25(1), 17–25 (Impact factor=2753)
Al-Balawi RS, Alshehri MA, Alatawi AS, Al Shehri AM, Alshehry MA, Al-Gayyar MM (2020): Measuring the appropriateness of carbamazepine and valproic acid prescribing and utilization using a newly implemented online system in the Tabuk Region of Saudi Arabia Saudi Pharm J, 28(7), 844–849 (Impact factor=433)
El-Far YM, Khodir AE, Emarah ZA, Ebrahim MA, Al-Gayyar MM (2020): Fucoidan Ameliorates Hepatocellular Carcinoma Induced in Rats: Effect on miR143 and Inflammation Nutr Cancer (Impact factor=2900)
Al-Gayyar MM (2020): Engaging Pharmacy Students in Interactive Life-Based Situations as the Basis for Teaching a Biochemistry Course Cureus 12(8): e9562 doi:107759/cureus9562
Alghandour R, Ebrahim M A, Ghazy H, Shamaa S, Emarah Z, Al-Gayyar MM (2020): Evaluation of the diagnostic and prognostic value of syndecan-1 in acute leukemia patients Cureus 12(9):e10594 doi:107759/cureus10594
Elsherbini AM, Maysarah NM, El-Sherbiny M, Al-Gayyar MM, Elsherbiny NM (2020): Glycyrrhizic acid ameliorates sodium nitrite-induced lung and salivary gland toxicity: Impact on oxidative stress, inflammation and fibrosis Hum Exp Toxicol (Impact factor=2903)
Alfaifi FF, Alghamdi AM, Al-omarani B, Dawaji EH, Aljabry H, Al-Gayyar MM (2020): Comprehensive study of scientific evidence and potential risk of herbal medicine use for body weight reduction in North West Saudi Arabia Cureus 12(10):e10903
Alshehri MA, Alshehri MM, Albalawi NN, Al-Ghamdi MA, Al-Gayyar MMH (2021): Heparan sulfate proteoglycans and their modification as promising anticancer targets in hepatocellular carcinoma (Review) Oncol Lett, 21(2):173 (Impact factor=2967)
Hassan HM, El-Kannishy SMH, Alattar A, Alshaman R, Hamdan AM, Al-Gayyar MMH (2021) Therapeutic effects of blocking β-catenin against hepatocellular carcinoma-induced activation of inflammation, fibrosis and tumor invasion Biomed Pharmacother, 135:111216 (Impact factor=6529)
Albalawi NN, Alshehri MM, Al-Ghamdi MA, Alshehri MA, Abdel-Maksoud MS, Al-Gayyar MM Impact of Knowledge and Attitude on Saudis’ Physical Activity Practice and Inactivity Barriers: A Questionnaire-based Study Open Access Maced J Med Sci, 8(E):1-9
Al-Gayyar MMH, Alattar A, Alshaman R, Hamdan AM (2021) QNZ alleviated hepatocellular carcinoma by targeting inflammatory pathways in a rat model Cytokine, 148:155710 (Impact factor=3861)

اسم المشروع	وصف المشروع
Evaluation of some biochemical molecules and other biochemical markers as prognostic factors in hematologic malignancies	Funded with 4000 $ by University of Mansoura in the period 18th October 2004
Study of the Diagnostic and prognostic significance of serum adiponectin and some mucopolysaccharides in patients with primary hepatocellular carcinoma	Funded with 5000 $ by University of Mansoura in the period 17th February 2008 to 4th June 2008
Study of the protective effects of Nigella oil on renal damage induced by oral chronic toxicity with sodium nitrite in food	Funded with 36,400 SAR by Deanship of Scientific Research (DSR), University of Tabuk, Tabuk, Saudi Arabia, under grant number S-1436-0007
Treatment of hepatocellular carcinoma by targeting sulfatase-2 induced inflammation	Funded with 20,000 SAR by Deanship of Scientific Research (DSR), University of Tabuk, Tabuk, Saudi Arabia, under grant number S-1438-0003
In vitro study of the therapeutic effects of nicotinamide in hepatocellular carcinoma through affecting the balance between mitogen activated protein kinase and protein kinase B	Funded with 20,000 SAR by Deanship of Scientific Research (DSR), University of Tabuk, Tabuk, Saudi Arabia, under grant number S-1439-0003

الكلية

كلية الصيدلة

التخصص العام

الكيمياء الصيدلية

التخصص الدقيق

الكيمياء الحيوية

الدرجة العلمية (المرتبة)

دكتوراه

الجنسية

المصرية

المسمى الوظيفي

استاذ

تاريخ آخر تعديل:2025/07/08 - 11:00 صباحا13/محرم/1447 - 14:00بتوقيت السعودية

malgayyar@ut.edu.sa

محمد محمد حلمي عبد الرحمن الجيار

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