نزار سراج الطيب مونه

استاذ مساعد في علم العقاقير متخصص في دراسة النواتج الطبيعية وفصل المواد الغعالة والتعرف عليها ودراسة تأثيراتها الطبية

السيرة الذاتية

جدول الدراسة

الابحاث والمؤلفات

المشاريع البحثية

الجوائز

اليوم	المادة	الوقت
		من	إلى
الأحد	Pharmaceutical Field Training III Sunday	08:00	15:00
الإثنين	Evidence-based herbal medicine	09:00	12:00
الخميس	Evidence-based herbal medicine	11:00	12:00
الخميس	Evidence-based herbal medicine	13:00	15:00

1 Nizar, S and Elhadi ,MA (2007) Hypoglycemic Activity of Nineteen Medicinal Plants in Sudan, Omdurman Journal of Pharmaceutical sciences, Vol1No (3):357-366 From Master thesis
2 Nizar, S Elhadi ,MA and Hassan ,SK (2007) Hypoglycemic, Phytochemical and other properties of Allium cepa LGezira Journal of Health Sciences, Vol3No (2):81-92 From Master thesis
3 Sit Elbanat,Y ,Elhadi,MAMirghani,A and Nizar,S(2008)Antimicrobial Activity of Fifteen Medicinal Plants on Hospital Air Contaminants Albuhuth Scientific Journal, 12(2):83-92
4 Nizar ,S Sit Elbanat, Y and Mirghani,A (2009)Antimicrobial Activity of Three Medicinal Plants Gezira Journal of Health Sciences, Vol 5(2):45-50
5 Elhadi,MAAfaf , MElgailani ,T Omer, M and Nizar ,S(2009)Quality Assurance of Essential Medicines on the Local Market: Assay of Content and in vitro Bioavailability-1:(Ciprofloxacin, Paracetamol and Amoxicillin) Oral Solid Dosage Forms Omdurman Journal of Pharmaceutical SciencesVol 1(5): 597-608
6 Mirghani,ANizar,SElmustafa,MOMustafa,MIandBella,MM(2011) Investigation of Medication Prescribing Errors in Wad Medani,Gezira,SudanInternational Journal of Risk and Safety in Medicines,23:11-1
7 Nizar,SHana,AAnwar ,AHozeiffa,MAl-dalou,S and Mirghani,A (2011)Investigation of the Safety of Prescribing Drugs during Pregnancy Arab journal of Pharmaceutical Sciences, 7(4):77-83
8 Nizar,SSitelbanat,YMustafa,I Al-dalou,S and Mirghani,A (2011) Investigation of Self-medication with Antibiotics, Sudan Study Arab journal of Pharmaceutical Sciences, 7(4):105-110
9 Hozeifa, MH Taj Eldin, IM Elhadi MA Abd Elwahab HM and Nizar, S (2012) The relaxant effect of Yohimbe bark (Pausinystalia yohimbe) on rabbit corpus cavernosum smooth muscles Journal of Health, 4(9):656-659
10 Hozeifa, MH Taj Eldin ,IM Elhadi MA Abd Elwahab HM and Nizar, S (2012) Effects of Methanolic Extract of Pausinystalia yohimbe Bark on Blood Glucose level in Normal Fasting Rats Journal of Health, 4(12):1225-1228
11 Hozeifa, MH Taj Eldin ,IM Elhadi MA Abd Elwahab HM and Nizar, S(2013)Effects of Methanolic Extract of Yohimbe bark (Pausinystalia yohimbe) on isolated rabbit aortic strip and rat uterus Journal of Health, 5(6):1016-1020
12 Nizar Sirag, Elhadi M Ahmed, Anwar Mohammed and Mohamed Abubakr (2013) Antibacterial Activity and Preliminary Phytochemical Screening of Four Medicinal Plants Gezira Journal of Engineering and Applied Sciences, 8(1):53-66
13 Nizar Sirag, Elhadi MM, Algaili M Algaili and Hozeifa Mohamed Hassan and Imad M Tajeldeen (2013)Effect of Hibiscus sabdariffa calyx Extract on Reproductive Hormones in Normal Rats African Journal of Pharmacy and Pharmacology, 7(32):2295-2298 From PhD Thesis
14 Mohamed Abubakr, Nizar Sirag , Ibrahim Osman , Mohamed Osman, Salihabakar and Ahmed M Aboul-Enein(2013) Anticancer and antioxidant activities of Guiera senegalensisSudan journal of medical sciences, 8(2):135-140
15 Abuabker Elbur, Yousif MA, Elbur AI, Bin Shahna M, Izham MI, Taib NS, Elmustafa MO, Abdoon S, Ibrahim M(2013) Skills Acquired during Baccalaureate Degree: Evaluation Study among Practicing Pharmacists in Sudan International Journal of Pharmacy Teaching & Practices, Vol4, Issue 1, 516-521 516
16 Nizar Sirag, Elhadi MM, Algaili M Algaili and Hozeifa Mohamed Hassan (2013) Antibacterial Activity of Roselle (Hibiscus sabdariffa L) Calyx Extract International Journal of Indigenous Medicinal Plants, 46(4):1487-1491
17 Eman Hassan A Rahman, Elhadi M Ahmed, and Nizar Sirag Standardization of Roselle (Hibiscus sabdariffa L) Calyx cultivated in Sudan (2014) Journal of Medicinal plant research, 8(4):217-222
18 Mirghani A Yousif Ahmed S Eldalo Ahmed A Albarraq Nizar Sirag Mustafa Ibrahim (2014) Pharmacy students’ perception about education and future career Archives of Pharmacy Practice, 5(2):72-77
Enas M Awad, Nizar Sirag and Elhadi M (2014) Anticonvulsant activity of Capsicum annum (Red Pepper) Fruit Extract using Pentylentetrazole and Maximum Electroshock Induced Seizure Tests in Rats Sudan Journal of Medical Sciences, 9(2):81-84
20 Nizar Sirag, Elhadi MM, Algaili M Algaili Hozeifa Mohamed Hassan and Mohamed Ohaj(2014) Determination of Total Phenolic Content and Antioxidant Activity of Roselle (Hibiscus sabdariffa L) Calyx ethanolic extract Standard Research Journal of Pharmacy and Pharmacology Vol1 (2): 034-039
21 Enas M Awad, Nizar Sirag , Alla Wad Allah and Elhadi MM(2014) Investigation of Anti-nociceptive Activity of Neem (Azadirachta indica) on acetic acid induced writhing in rats Gezira Journal of Health sciences,10(1):37-43
Nizar Sirag,Anwar Mohammed , Abdelgadir Alamin , Mohamed Abubaker,andMusa Elhadi(2014) Antibacterial Activity of Six Medicinal Plants Alneelain Journal of Medical Sciences
23 Mohamed Abubaker Mohamed Osman Salihabakar and Nizar Sirag(2014) Determination of total phenolic content and antioxidant capacity of three Sudanese medicinal plants Gezira Journal of Engineering and Applied Sciences,9(1):62-72
24 Nizar Sirag ,Enas M Awad, and Elhadi M (2015) Investigation of Anti-nociceptive Activity of Sage (Salvia officinalis) on acetic acid induced writhing in rats Pyrex Journal of Medicinal plant research, 1(1):1-4
25 Ahmed S Eldalo, Nizar Sirag, Yousif MA(2015) Pregnant Womens Awareness and Perception about Medicines Latin American Journal of Pharmacy 34 (5): 869-74
Hebatallah Husseini Atteia , Eman Saad Alamri, Nizar Sirag, Nahla Salah Zidan, Raghad Humod Aljohani f, Sharifa Alzahrani g, Manar Hamed Arafa h, Nanies Sameeh Mohammad, Mervat Elsayed Asker, Sawsan A Zaitone, Amr Tawfik Sakr (2023)Soluble guanylate cyclase agonist, isoliquiritigenin attenuates renal damage and aortic calcification in a rat model of chronic kidney failure Life Sciences 317: 121460
Hetta, HF Sirag, N Alsharif, SM Alharbi, AA Alkindy, TT Alkhamali, A Albalawi, AS Ramadan, YN Rashed, ZI Alanazi, FE Antimicrobial Peptides: The Game-Changer in the Epic Battle Against Multidrug-Resistant Bacteria Pharmaceuticals 2024, 17, 1555 https://doiorg/103390/ ph17111555
29 Ramadan Ali, Hassabelrasoul Elfadil, Nizar Sirag, Abdullah S Albalawi, Amjad Albalawi, Salma Alharbi, Alanoud Al-anzi, Shatha Alatawi, Yusra Alhuaiti, Faleh Turki Alsubaie, Nawaf Aldwsari, Mohamed M El-Wekil, A novel red emissive glutathione-capped carbon dots embedded within molecularly-imprinted polymers for adsorption and fluorescent sensing of malachite green in food samples Microchemical Journal, Volume 212, 2025
Hetta, Helal F, Nizar Sirag, Hassabelrasoul Elfadil, Ayman Salama, Sara F Aljadrawi, Amani J Alfaifi, Asma N Alwabisi, Bothinah M AbuAlhasan, Layan S Alanazi, Yara A Aljohani, 2025 "Artificial Sweeteners: A Double-Edged Sword for Gut Microbiome" Diseases 13, no 4: 115
Alqahtani S, Alqahtani T, Venkatesan K, Sivadasan D, Ahmed R, Sirag N, Elfadil H, Abdullah Mohamed H, T A H, Elsayed Ahmed R, Muralidharan P, Paulsamy P SASP Modulation for Cellular Rejuvenation and Tissue Homeostasis: Therapeutic Strategies and Molecular Insights Cells 2025 Apr 1714(8):608 doi: 103390/cells14080608 PMID: 40277933 PMCID: PMC12025513

اسم المشروع	وصف المشروع
Computational and Biological Evaluation of Naturally Derived Phytochemicals as Modulators of Mitochondrial Dynamics	In our approach, we are going to perform virtual screening via molecular docking and computational analysis to examine the affinity of a library of phytochemicals of well-known antioxidant activity towards Drp1 and other proteins involved in the mitochondrial fission, then we will test the mitochondrial fission inhibitory effect of the phytochemicals with high affinity scores in biological systems like budding yeast, cell cultures, neurons and in cancer cell lines We are planning to configure the physiological outcome of those inhibitors of mitochondrial fission after inducing mitochondrial fragmentation Our approach is going to assign novel ameliorative capacity of antioxidants of herbal origin through modulating the mitochondrial dynamics
Anti-inflammatory and antioxidant effect of paeonol on autism spectrum disorder in infantile rats: possible inhibition of heat shock protein 90	Autism pectrum disorder (ASD) is termed as exceeded inattention and hyperactivity Neuroinflammation and oxidative stress are complicated in the pathology of ASD Paeonol is the main component isolated from the root bark of Paeonia suffruticosa with potent antioxidant and anti-inflammatory activities Paeonol displays broad antioxidants and may play a therapeutic role in ASD Male albino rat pups will be allocated to three experimental groups: (i): normal, (ii): ASD group, (iii) ASD + Paeonol-50 mg/kg We will induce ASD by prenatal administration of valproate sodium Cognitive and motor dysfunction will be evaluated using the elevated plus maze test (EPM) for assessing anxiety behavior, and the attentional set-shifting task (ASST) for assessing attention and compulsive behaviors In addition, brain histopathologic examination will help assessment of brain injury in infantile rats after staining with hematoxylin and eosin, toluidine blue and silver staining These stains will show the main pathologies in the different hippocampal areas (dentate gyrus, CA1, CA2, and CA3) and the cerebral cortex Each stain will indicate certain pathology some stains are directed towards labeling the dead or pyknotic neurons but others are directed toward labeling surviving neurons Furthermore, molecular docking and bioinformatic studies will help in the determination of the mechanism of action of paeonol and following the suggestion that paeonol may inhibit heat shock protein-90 (HSP90)

اسم المشروع

وصف المشروع

Computational and Biological Evaluation of Naturally Derived Phytochemicals as Modulators of Mitochondrial Dynamics

In our approach, we are going to perform virtual screening via molecular docking and computational analysis to examine the affinity of a library of phytochemicals of well-known antioxidant activity towards Drp1 and other proteins involved in the mitochondrial fission, then we will test the mitochondrial fission inhibitory effect of the phytochemicals with high affinity scores in biological systems like budding yeast, cell cultures, neurons and in cancer cell lines We are planning to configure the physiological outcome of those inhibitors of mitochondrial fission after inducing mitochondrial fragmentation Our approach is going to assign novel ameliorative capacity of antioxidants of herbal origin through modulating the mitochondrial dynamics

Anti-inflammatory and antioxidant effect of paeonol on autism spectrum disorder in infantile rats: possible inhibition of heat shock protein 90

Autism pectrum disorder (ASD) is termed as exceeded inattention and hyperactivity Neuroinflammation and oxidative stress are complicated in the pathology of ASD Paeonol is the main component isolated from the root bark of Paeonia suffruticosa with potent antioxidant and anti-inflammatory activities Paeonol displays broad antioxidants and may play a therapeutic role in ASD Male albino rat pups will be allocated to three experimental groups: (i): normal, (ii): ASD group, (iii) ASD + Paeonol-50 mg/kg We will induce ASD by prenatal administration of valproate sodium Cognitive and motor dysfunction will be evaluated using the elevated plus maze test (EPM) for assessing anxiety behavior, and the attentional set-shifting task (ASST) for assessing attention and compulsive behaviors In addition, brain histopathologic examination will help assessment of brain injury in infantile rats after staining with hematoxylin and eosin, toluidine blue and silver staining These stains will show the main pathologies in the different hippocampal areas (dentate gyrus, CA1, CA2, and CA3) and the cerebral cortex Each stain will indicate certain pathology some stains are directed towards labeling the dead or pyknotic neurons but others are directed toward labeling surviving neurons Furthermore, molecular docking and bioinformatic studies will help in the determination of the mechanism of action of paeonol and following the suggestion that paeonol may inhibit heat shock protein-90 (HSP90)

الكلية

كلية الصيدلة

التخصص العام

النواتج الطبيعية

التخصص الدقيق

العقاقير

الدرجة العلمية (المرتبة)

دكتوراه

الجنسية

السودانية

المسمى الوظيفي

أستاذ مساعد

تاريخ آخر تعديل:2026/01/11 - 09:05 ص22/رجب/1447 - 12:05بتوقيت السعودية

اليوم	المادة	الوقت
الأحد	Pharmaceutical Field Training III Sunday	08:00	15:00
الإثنين	Evidence-based herbal medicine	09:00	12:00
الخميس	Evidence-based herbal medicine	11:00	12:00
الخميس	Evidence-based herbal medicine	13:00	15:00

1 Nizar, S and Elhadi ,MA (2007) Hypoglycemic Activity of Nineteen Medicinal Plants in Sudan, Omdurman Journal of Pharmaceutical sciences, Vol1No (3):357-366 From Master thesis
2 Nizar, S Elhadi ,MA and Hassan ,SK (2007) Hypoglycemic, Phytochemical and other properties of Allium cepa LGezira Journal of Health Sciences, Vol3No (2):81-92 From Master thesis
3 Sit Elbanat,Y ,Elhadi,MAMirghani,A and Nizar,S(2008)Antimicrobial Activity of Fifteen Medicinal Plants on Hospital Air Contaminants Albuhuth Scientific Journal, 12(2):83-92
4 Nizar ,S Sit Elbanat, Y and Mirghani,A (2009)Antimicrobial Activity of Three Medicinal Plants Gezira Journal of Health Sciences, Vol 5(2):45-50
5 Elhadi,MAAfaf , MElgailani ,T Omer, M and Nizar ,S(2009)Quality Assurance of Essential Medicines on the Local Market: Assay of Content and in vitro Bioavailability-1:(Ciprofloxacin, Paracetamol and Amoxicillin) Oral Solid Dosage Forms Omdurman Journal of Pharmaceutical SciencesVol 1(5): 597-608
6 Mirghani,ANizar,SElmustafa,MOMustafa,MIandBella,MM(2011) Investigation of Medication Prescribing Errors in Wad Medani,Gezira,SudanInternational Journal of Risk and Safety in Medicines,23:11-1
7 Nizar,SHana,AAnwar ,AHozeiffa,MAl-dalou,S and Mirghani,A (2011)Investigation of the Safety of Prescribing Drugs during Pregnancy Arab journal of Pharmaceutical Sciences, 7(4):77-83
8 Nizar,SSitelbanat,YMustafa,I Al-dalou,S and Mirghani,A (2011) Investigation of Self-medication with Antibiotics, Sudan Study Arab journal of Pharmaceutical Sciences, 7(4):105-110
9 Hozeifa, MH Taj Eldin, IM Elhadi MA Abd Elwahab HM and Nizar, S (2012) The relaxant effect of Yohimbe bark (Pausinystalia yohimbe) on rabbit corpus cavernosum smooth muscles Journal of Health, 4(9):656-659
10 Hozeifa, MH Taj Eldin ,IM Elhadi MA Abd Elwahab HM and Nizar, S (2012) Effects of Methanolic Extract of Pausinystalia yohimbe Bark on Blood Glucose level in Normal Fasting Rats Journal of Health, 4(12):1225-1228
11 Hozeifa, MH Taj Eldin ,IM Elhadi MA Abd Elwahab HM and Nizar, S(2013)Effects of Methanolic Extract of Yohimbe bark (Pausinystalia yohimbe) on isolated rabbit aortic strip and rat uterus Journal of Health, 5(6):1016-1020
12 Nizar Sirag, Elhadi M Ahmed, Anwar Mohammed and Mohamed Abubakr (2013) Antibacterial Activity and Preliminary Phytochemical Screening of Four Medicinal Plants Gezira Journal of Engineering and Applied Sciences, 8(1):53-66
13 Nizar Sirag, Elhadi MM, Algaili M Algaili and Hozeifa Mohamed Hassan and Imad M Tajeldeen (2013)Effect of Hibiscus sabdariffa calyx Extract on Reproductive Hormones in Normal Rats African Journal of Pharmacy and Pharmacology, 7(32):2295-2298 From PhD Thesis
14 Mohamed Abubakr, Nizar Sirag , Ibrahim Osman , Mohamed Osman, Salihabakar and Ahmed M Aboul-Enein(2013) Anticancer and antioxidant activities of Guiera senegalensisSudan journal of medical sciences, 8(2):135-140
15 Abuabker Elbur, Yousif MA, Elbur AI, Bin Shahna M, Izham MI, Taib NS, Elmustafa MO, Abdoon S, Ibrahim M(2013) Skills Acquired during Baccalaureate Degree: Evaluation Study among Practicing Pharmacists in Sudan International Journal of Pharmacy Teaching & Practices, Vol4, Issue 1, 516-521 516
16 Nizar Sirag, Elhadi MM, Algaili M Algaili and Hozeifa Mohamed Hassan (2013) Antibacterial Activity of Roselle (Hibiscus sabdariffa L) Calyx Extract International Journal of Indigenous Medicinal Plants, 46(4):1487-1491
17 Eman Hassan A Rahman, Elhadi M Ahmed, and Nizar Sirag Standardization of Roselle (Hibiscus sabdariffa L) Calyx cultivated in Sudan (2014) Journal of Medicinal plant research, 8(4):217-222
18 Mirghani A Yousif Ahmed S Eldalo Ahmed A Albarraq Nizar Sirag Mustafa Ibrahim (2014) Pharmacy students’ perception about education and future career Archives of Pharmacy Practice, 5(2):72-77
Enas M Awad, Nizar Sirag and Elhadi M (2014) Anticonvulsant activity of Capsicum annum (Red Pepper) Fruit Extract using Pentylentetrazole and Maximum Electroshock Induced Seizure Tests in Rats Sudan Journal of Medical Sciences, 9(2):81-84
20 Nizar Sirag, Elhadi MM, Algaili M Algaili Hozeifa Mohamed Hassan and Mohamed Ohaj(2014) Determination of Total Phenolic Content and Antioxidant Activity of Roselle (Hibiscus sabdariffa L) Calyx ethanolic extract Standard Research Journal of Pharmacy and Pharmacology Vol1 (2): 034-039
21 Enas M Awad, Nizar Sirag , Alla Wad Allah and Elhadi MM(2014) Investigation of Anti-nociceptive Activity of Neem (Azadirachta indica) on acetic acid induced writhing in rats Gezira Journal of Health sciences,10(1):37-43
Nizar Sirag,Anwar Mohammed , Abdelgadir Alamin , Mohamed Abubaker,andMusa Elhadi(2014) Antibacterial Activity of Six Medicinal Plants Alneelain Journal of Medical Sciences
23 Mohamed Abubaker Mohamed Osman Salihabakar and Nizar Sirag(2014) Determination of total phenolic content and antioxidant capacity of three Sudanese medicinal plants Gezira Journal of Engineering and Applied Sciences,9(1):62-72
24 Nizar Sirag ,Enas M Awad, and Elhadi M (2015) Investigation of Anti-nociceptive Activity of Sage (Salvia officinalis) on acetic acid induced writhing in rats Pyrex Journal of Medicinal plant research, 1(1):1-4
25 Ahmed S Eldalo, Nizar Sirag, Yousif MA(2015) Pregnant Womens Awareness and Perception about Medicines Latin American Journal of Pharmacy 34 (5): 869-74
Hebatallah Husseini Atteia , Eman Saad Alamri, Nizar Sirag, Nahla Salah Zidan, Raghad Humod Aljohani f, Sharifa Alzahrani g, Manar Hamed Arafa h, Nanies Sameeh Mohammad, Mervat Elsayed Asker, Sawsan A Zaitone, Amr Tawfik Sakr (2023)Soluble guanylate cyclase agonist, isoliquiritigenin attenuates renal damage and aortic calcification in a rat model of chronic kidney failure Life Sciences 317: 121460
Hetta, HF Sirag, N Alsharif, SM Alharbi, AA Alkindy, TT Alkhamali, A Albalawi, AS Ramadan, YN Rashed, ZI Alanazi, FE Antimicrobial Peptides: The Game-Changer in the Epic Battle Against Multidrug-Resistant Bacteria Pharmaceuticals 2024, 17, 1555 https://doiorg/103390/ ph17111555
29 Ramadan Ali, Hassabelrasoul Elfadil, Nizar Sirag, Abdullah S Albalawi, Amjad Albalawi, Salma Alharbi, Alanoud Al-anzi, Shatha Alatawi, Yusra Alhuaiti, Faleh Turki Alsubaie, Nawaf Aldwsari, Mohamed M El-Wekil, A novel red emissive glutathione-capped carbon dots embedded within molecularly-imprinted polymers for adsorption and fluorescent sensing of malachite green in food samples Microchemical Journal, Volume 212, 2025
Hetta, Helal F, Nizar Sirag, Hassabelrasoul Elfadil, Ayman Salama, Sara F Aljadrawi, Amani J Alfaifi, Asma N Alwabisi, Bothinah M AbuAlhasan, Layan S Alanazi, Yara A Aljohani, 2025 "Artificial Sweeteners: A Double-Edged Sword for Gut Microbiome" Diseases 13, no 4: 115
Alqahtani S, Alqahtani T, Venkatesan K, Sivadasan D, Ahmed R, Sirag N, Elfadil H, Abdullah Mohamed H, T A H, Elsayed Ahmed R, Muralidharan P, Paulsamy P SASP Modulation for Cellular Rejuvenation and Tissue Homeostasis: Therapeutic Strategies and Molecular Insights Cells 2025 Apr 1714(8):608 doi: 103390/cells14080608 PMID: 40277933 PMCID: PMC12025513

اسم المشروع	وصف المشروع
Computational and Biological Evaluation of Naturally Derived Phytochemicals as Modulators of Mitochondrial Dynamics	In our approach, we are going to perform virtual screening via molecular docking and computational analysis to examine the affinity of a library of phytochemicals of well-known antioxidant activity towards Drp1 and other proteins involved in the mitochondrial fission, then we will test the mitochondrial fission inhibitory effect of the phytochemicals with high affinity scores in biological systems like budding yeast, cell cultures, neurons and in cancer cell lines We are planning to configure the physiological outcome of those inhibitors of mitochondrial fission after inducing mitochondrial fragmentation Our approach is going to assign novel ameliorative capacity of antioxidants of herbal origin through modulating the mitochondrial dynamics
Anti-inflammatory and antioxidant effect of paeonol on autism spectrum disorder in infantile rats: possible inhibition of heat shock protein 90	Autism pectrum disorder (ASD) is termed as exceeded inattention and hyperactivity Neuroinflammation and oxidative stress are complicated in the pathology of ASD Paeonol is the main component isolated from the root bark of Paeonia suffruticosa with potent antioxidant and anti-inflammatory activities Paeonol displays broad antioxidants and may play a therapeutic role in ASD Male albino rat pups will be allocated to three experimental groups: (i): normal, (ii): ASD group, (iii) ASD + Paeonol-50 mg/kg We will induce ASD by prenatal administration of valproate sodium Cognitive and motor dysfunction will be evaluated using the elevated plus maze test (EPM) for assessing anxiety behavior, and the attentional set-shifting task (ASST) for assessing attention and compulsive behaviors In addition, brain histopathologic examination will help assessment of brain injury in infantile rats after staining with hematoxylin and eosin, toluidine blue and silver staining These stains will show the main pathologies in the different hippocampal areas (dentate gyrus, CA1, CA2, and CA3) and the cerebral cortex Each stain will indicate certain pathology some stains are directed towards labeling the dead or pyknotic neurons but others are directed toward labeling surviving neurons Furthermore, molecular docking and bioinformatic studies will help in the determination of the mechanism of action of paeonol and following the suggestion that paeonol may inhibit heat shock protein-90 (HSP90)

اسم المشروع

وصف المشروع

Computational and Biological Evaluation of Naturally Derived Phytochemicals as Modulators of Mitochondrial Dynamics

Anti-inflammatory and antioxidant effect of paeonol on autism spectrum disorder in infantile rats: possible inhibition of heat shock protein 90