MOHAMED SAMIR ABDELMAKSOUD MEGAHED

Experience and administrative positions

منسق المعامل الطلابية والبحثية
منسق الأنشطة الطلابية بكلية الصيدلة
المنسق الإعلامي للكلية
منسق السنة التحضيرية بالكلية
مشرف وحدة الخريجين بكلية الصيدلة
مشرف الجودة بقسم علم الأدوية والسموم

Qualifications

بكالوريوس العلوم الصيدلية - جامعة عين شمس (جمهورية مصر العربية) 2007
ماجستير العلوم الصيدلية تخصص أدوية وسموم - جامعة قناة السويس (جمهورية مصر العربية) 2013
دكتوراة في العلوم الصيدلية تخصص أدوية وسموم - جامعة قناة السويس (جمهورية مصر العربية) 2018

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Research interests

Evaluation the use of stem cells in treatment of chronic diseases

The use of herbal products in treatment of inflammatory disorders

The use of exosomes in targeting the CNS and treatment of neurological disorders

Evaluation new therapeutic strategies in treatment of Alzeheimer diseases

Day	Course	Time
الأحد	علم السموم - نظري - طلاب	10:00 - 12:00
الأحد	علم السموم- عملي - طلاب	13:00 - 15:00
الإثنين	ساعات مكتبية	09:00 - 11:00
الإثنين	ساعات مكتبية	13:00 - 15:00
الثلاثاء	إرشاد أكاديمي	09:00 - 11:00
الثلاثاء	علم الأدوية التطبيقي -1 - نظري - طلاب	12:00 - 13:00
الثلاثاء	علم السموم- عملي - طالبات	13:00 - 15:00
الأربعاء	مصطلحات طبية - نظري - طلاب	09:00 - 11:00
الأربعاء	مصطلحات طبية - تدريب - طلاب	11:00 - 12:00
الخميس	علم الأدوية التطبيقي -1 - نظري - طالبات	11:00 - 12:00

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• Ghadi N Alzhrani, Sarah T Alanazi, Sumayyah Y Alsharief, Amani M Albalawi, Anwar A Alsharief, Mohamed S Abdel-maksoud, Nehal Elsherbiny (2021): Exosomes: Isolation, Characterization and Biomedical Applications, Cell Biology International (In press)
• Naif N Albalawi, Moath M Alshehri, Moshari A Al-Ghamdi, Mohammed A Alshehri, Mohamed S Abdel-Maksoud, Mohammed M H Al-Gayyar (2021): Impact of Knowledge and Attitude on Saudis’ Physical Activity Practice and Inactivity Barriers: A Questionnaire-based Study, Macedonian Journal of Medical Sciences 2021 Jan 23 9(E):50-58
• Shumukh M Alatyyat, Houton M Alasmari, Omamah A Aleid, Mohamed S Abdel-maksoud, Nehal Elsherbiny (2020): Umbilical cord stem cells: Background, processing and applications, Tissue and Cell (65):101351
• Mohamed S Abdel-Maksoud, Mona F El-Azab, Moushira I El Sayed, Yasser M Moustafa (2018): Huntington’s disease and NMDA receptors a new arena for therapeutic development, Records of Pharmaceutical and Biomedical Sciences
• Sherif El-Kannishy, Aalaa Aboelnour, Waleed Barakat, Mohamed S Abdel-Maksoud, and Abdullah A AL Yousef (2016): Endocrinal dysfunction of hypothalamo-pitutary gonadal axis in seminal plasma of cigarette smoking males, Research Journal of Pharmaceutical, Biological and Chemical Sciences 7 (1): 461-468
• Mohamed S Abdel-Maksoud, Medhat I Abdel-hamid, Yasser M Moustafa (2012): NMDA/glutamate mechanism of anxiolytic-like action of zinc in Vogel conflict test in mice International Organization of Scientific Research, Journal of Pharmacy 2 (5): 4-12

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Project Name	Project Description
Role of diacerein in enhancing the anti-tumor effect of 5-Fluorouracil and combating its induced hepatorenal toxicity in experimental breast cancer: Effect on TLR4/ NF-κB/NLRP3 axis	5-Fluorouracil (5-FU) is a frontline chemotherapeutic agent However, its clinical application is limited by development of chemoresistance and serious organ toxicity These shortcomings decrease 5-FU tolerability, leading to compromised therapeutic outcomes, poor quality of life and increased mortality of cancer patients The Saudi Vision 2030 is focusing on providing best therapeutic services and improving well-being of Saudi-population Therefore, the present protocol aims to shed the light on new therapeutic approach to enhance anti-tumorigenicity and reduce organ toxicity of 5-FU Diacerein (DIA) is an anti-inflammatory drug currently prescribed for treatment of osteoarthritis However, recent reports have demonstrated its anti-proliferative and chemo-sensitizing activities The present protocol will evaluate the chemo-sensitizing and hepatorenal protective efficacies of combined DIA and 5-FU administration in breast cancer, the most diagnosed malignancy among Saudi women For this purpose, Ehrlich solid tumor, a spontaneous murine mammary adenocarcinoma will be induced in female Swiss mice The effect of DIA and/or 5-FU treatment on animal survival, tumor growth, liver and kidney function tests will be assessed Moreover, gene and protein levels of key-effectors coherent with carcinogenesis and hepatorenal injury including oxidative stress, inflammation and apoptosis will be evaluated using real time polymerase chain reaction, enzyme-linked immunosorbent assay, histopathology and immunohistochemistry

Project Name

Project Description

Role of diacerein in enhancing the anti-tumor effect of 5-Fluorouracil and combating its induced hepatorenal toxicity in experimental breast cancer: Effect on TLR4/ NF-κB/NLRP3 axis

5-Fluorouracil (5-FU) is a frontline chemotherapeutic agent However, its clinical application is limited by development of chemoresistance and serious organ toxicity These shortcomings decrease 5-FU tolerability, leading to compromised therapeutic outcomes, poor quality of life and increased mortality of cancer patients The Saudi Vision 2030 is focusing on providing best therapeutic services and improving well-being of Saudi-population Therefore, the present protocol aims to shed the light on new therapeutic approach to enhance anti-tumorigenicity and reduce organ toxicity of 5-FU Diacerein (DIA) is an anti-inflammatory drug currently prescribed for treatment of osteoarthritis However, recent reports have demonstrated its anti-proliferative and chemo-sensitizing activities The present protocol will evaluate the chemo-sensitizing and hepatorenal protective efficacies of combined DIA and 5-FU administration in breast cancer, the most diagnosed malignancy among Saudi women For this purpose, Ehrlich solid tumor, a spontaneous murine mammary adenocarcinoma will be induced in female Swiss mice The effect of DIA and/or 5-FU treatment on animal survival, tumor growth, liver and kidney function tests will be assessed Moreover, gene and protein levels of key-effectors coherent with carcinogenesis and hepatorenal injury including oxidative stress, inflammation and apoptosis will be evaluated using real time polymerase chain reaction, enzyme-linked immunosorbent assay, histopathology and immunohistochemistry

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جائزة عضو هيئة التدريس المتميز في مجال خدمة المجتمع لعام 1442 هــ