الصفحة الرئيسية

كلية العلوم \ الكيمياء الحيوية

محمد ريحان أجمل خان

السيرة الذاتية
نسبة اكتمال الملف الشخصي
الجنسية الهندية
التخصص العام الكيمياء
التخصص الدقيق كيمياء حيوية
المسمى الوظيفي أستاذ مساعد
الدرجة العلمية (المرتبة) دكتوراه

نبذه مختصرة

Protein ligand interaction is important in food sciences studies imparting flavors and texture to food that is also one of the important are of research that need to focus Nature derived molecules like polyphenols, alkaloids and other secondary metabolites have found application in variety of research area from treatment of cancers to fight infections Our research group will focus on finding natural molecules interacting with target proteins in human diseases to find possible cure for many debilitating human diseases We will be able to have high quality publications and generating intellectual property Academic research is important part for scientific advancement and enhancement for any educational institute

المؤهلات العلمية

Bachelor of science master of science doctor of philosophy-PhD CSIR UGC JRF DBT JRF

الاهتمامات البحثية

Protein Ligand Interactions protein misfolding and aggregation Amyloids and their applications biopolymer applications in environmental pollutant removal and mitigation

الخبرات والمناصب الإدارية

1-Working as active member of department council, Department of Biochemistry, Faculty of Science University of Tabuk, Tabuk Kingdom of Saudi Arabia 2- Serving as member of department quality and accreditation committee for undergraduate program 3-Serving as member of department laboratory committee for undergraduate program 4- Serving as member of faculty research laboratory- coordinating member physical biochemistry research laboratory, Faculty of science University of Tabuk, Tabuk Kingdom of Saudi Arabia

الجدول الدراسي
اليوم المادة الوقت
من إلى
الأحد fundamentals of biochemistry 08:00 10:00
الأحد research essays in biochemistry 18:00 21:00
الأحد research essays in biochemistry 18:00 21:00
الإثنين physical biochemistry 10:00 12:00
الإثنين physical biochemistry 12:00 14:00
الإثنين fundamentals of biochemistry 14:00 16:00
الإثنين immunology 17:00 18:30
الثلاثاء research essays in biochemistry 18:00 21:00
الأربعاء analytical biochemistry 10:00 12:00
الأربعاء physical biochemistry 12:00 14:00
الأربعاء immunology 17:00 18:30
الأبحاث والمؤلفات
  • Levofloxacin-Induced Insulin Aggregation: Biophysical and Computational Insights into Amyloidogenic Potential F Nabi, O Ahmad, K Varshney, MR Ajmal, FM Almutairi, R Mir, J Javid, Journal of Computational Biophysics and Chemistry
  • Efficient hydrogen peroxide reduction in glutathione peroxidase cycle using cost-effective FeSe2 nanospheres S Khan, SS Bhagwath, MR Ajmal, IA Ansari, M Lohani, Frontiers in Agronomy 6, 1508794
  • The neural networking strategy results in the tri‐hybrid nanofluid flowing over a slippery flat plate to act as an antimicrobial agent through solar radiation MR Ajmal, T Gul, FM Almutairi, SAE Wanees, AS Alhawiti, H Ayed, ZAMM‐Journal of Applied Mathematics and Mechanics/Zeitschrift für Angewandte …
  • Approximation properties by shifted knots type of α-Bernstein–Kantorovich–Stancu operators M Nasiruzzaman, M Dilshad, BME Albalawi, MR Ajmal Journal of Inequalities and Applications 2024 (1), 85
  • Molecular Dynamics Simulation of Kir6 2 Variants Reveals Potential Association with Diabetes Mellitus ME Elangeeb, I Elfaki, AMS Eleragi, EM Ahmed, R Mir, SM Alzahrani, Molecules 29 (8), 1904
  • Cytotoxic and anti-metastatic action mediates the anti-proliferative activity of Rhazya stricta Decne inducing apoptotic cell death in human cancer cells: Implication in … MF Ullah, FM Abuduhier, SH Bhat, A Ahmad, MR Ajmal, SK Mustafa Emirates Journal of Food and Agriculture 8, 683-692
  • Protein misfolding and aggregation in proteinopathies: causes, mechanism and cellular response MR Ajmal Diseases 11 (1), 30
  • Binding of Novobiocin Paves the Way for Inhibition of DEAH-box Helicase 8 MR Ajmal, FM Almutairi, A Hussain, MF Ullah, MA Ahmad, Ind J Pharm Edu Res 57 (2s), s459-s464
  • Phytochemical Analysis and Binding Interaction of Cotton Seed Cake Derived Compounds with Target Protein of Meloidogyne incognita for Nematicidal Evaluation FM Almutairi, A Khan, MR Ajmal, RH Khan, MF Khan, H Lal, MF Ullah, Life 12 (12), 2109
  • On the binding reaction of loratadine with human serum acute phase protein alpha 1-acid glycoprotein FM Almutairi, MR Ajmal, MK Siddiqi, AI Alalawy, RH Khan Journal of Biomolecular Structure and Dynamics 40 (19), 9484-9491
  • Protective Effect of Catharanthus roseus Extract on Cadmium-Induced Toxicity in Albino Rats: A Putative Mechanism of Detoxification M Hashim, H Arif, B Tabassum, A Arif, AA Rehman, S Rehman, R Khanam, Metabolites 12 (11), 1059
  • Future Risk Analysis of the Health Public Sector During COVID-19 Period (2020 to March 2021) CR Telles, AM Ayaz, SK Mustafa, A Roy, MR Ajmal, EP Frigo Designing Intelligent Healthcare Systems, Products, and Services Using …
  • Moxifloxacin disrupts and attenuates Aβ42 fibril and oligomer formation: plausibly repositioning an antibiotic as therapeutic against Alzheimer’s disease AN Khan, F Nabi, MR Ajmal, SM Ali, FM Almutairi, AI Alalawy, RH Khan ACS Chemical Neuroscience 13 (16), 2529-2539
  • Luteolin causes 5′ CpG demethylation of the promoters of TSGs and modulates the aberrant histone modifications, restoring the expression of TSGs in human cancer cells S Pramodh, R Raina, A Hussain, SA Bagabir, S Haque, ST Raza, International journal of molecular sciences 23 (7), 4067
  • Mechanistic In Vitro Dissection of the Inhibition of Amyloid Fibrillation by n-Acetylneuraminic Acid: Plausible Implication in Therapeutics for Neurodegenerative … N Zaidi, MR Ajmal, SA Zaidi, RH Khan ACS Chemical Neuroscience 13 (1), 69-80
  • Biophysical insight into the interaction of levocabastine with human serum albumin: spectroscopy and molecular docking approach FM Almutairi, MR Ajmal, MK Siddiqi, N Majid, AIA Al-Alawy, Journal of Biomolecular Structure and Dynamics 39 (5), 1525-1534
  • Some aspects of modeling in the study of COVID-19 data SK Mustafa, V Lyashenko, NA Ahamad, MR Ajmal, MA Ahmad International Journal of Pharmaceutical Research
  • Chemical characterization of VARUMIN (1 and 2) oral solutions as potential therapeutic beverages V Pavlova, BB Popov, VK Hristova, SK MUSTAFA, AAA OYOUNI, Int J Pharm Res 12, 4454-4460
  • Multi-spectroscopic and molecular docking technique study of the azelastine interaction with human serum albumin FM Almutairi, MR Ajmal, MK Siddiqi, M Amir, RH Khan Journal of Molecular Structure 1201, 127147
  • Both beta sheet breaker and alpha helix forming pentapeptide inhibits protein fibrillation: Implication for the treatment of amyloid disorders MK Siddiqi, N Majid, P Alam, S Malik, A Alam, S Rajan, MR Ajmal, International journal of biological macromolecules 143, 102-111
  • Research Article Biophysical Insight into the Interaction of Human Lysozyme with Anticancer Drug Anastrozole: A Multitechnique Approach FM Almutairi, MR Ajmal, AI Al Alawy, RH Khan, AS Abdelhameed
  • COVID-19 and Immune Function–“A Significant Zinc MS Khalid, MMH Aljohani, NA Alomrani, AAA Oyouni, O Alzahrani, Oriental Journal of Chemistry 36 (6), 1026
  • Biophysical insight into the interaction of human lysozyme with anticancer drug anastrozole: a multitechnique approach FM Almutairi, MR Ajmal, AIA Alawy, RH Khan, AS Abdelhameed The Scientific World Journal 2020 (1), 8363685
  • Biophysical insights into the interaction of clofazimine with human alpha 1-acid glycoprotein: a multitechnique approach MR Ajmal, F Almutairi, N Zaidi, P Alam, MK Siddiqi, MV Khan, M Zaman, Journal of Biomolecular Structure and Dynamics 37 (6), 1390-1401
  • Systematic biophysical insights into the interaction of anti MERS-CoV drug ribavirin with major transport protein in human serum: In-vitro studies and implications in diabetes … F Almutairi, MR Ajmal Biophysical Journal 116 (3), 480a
  • Stabilizing proteins to prevent conformational changes required for amyloid fibril formation MK Siddiqi, P Alam, S Malik, N Majid, SK Chaturvedi, S Rajan, MR Ajmal, Journal of Cellular Biochemistry 120 (2), 2642-2656
  • Cationic surfactant mediated fibrillogenesis in bovine liver catalase: a biophysical approach MV Khan, M Zaman, TI Chandel, MK Siddiqui, MR Ajmal, Journal of Biomolecular Structure and Dynamics 36 (10), 2543-2557
  • Amino group of salicylic acid exhibits enhanced inhibitory potential against insulin amyloid fibrillation with protective aptitude toward amyloid induced cytotoxicity M Zaman, MV Khan, SM Zakariya, S Nusrat, SM Meeran, P Alam, Journal of Cellular Biochemistry 119 (5), 3945-3956
  • Biophysical insight reveals tannic acid as amyloid inducer and conformation transformer from amorphous to amyloid aggregates in Concanavalin A (ConA) MV Khan, M Ishtikhar, MK Siddiqui, M Zaman, TI Chandel, N Majid, Journal of Biomolecular Structure and Dynamics 36 (5), 1261-1273
  • Interaction of catecholamine precursor l-Dopa with lysozyme: a biophysical insight S Nusrat, A Masroor, M Zaman, MK Siddiqi, MR Ajmal, N Zaidi, International journal of biological macromolecules 109, 1132-1139
  • Investigating the site selective binding of busulfan to human serum albumin: Biophysical and molecular docking approaches M Siddiqi, S Nusrat, P Alam, S Malik, SK Chaturvedi, MR Ajmal, International journal of biological macromolecules 107, 1414-1421
  • Biophysical insight into the interaction mechanism of plant derived polyphenolic compound tannic acid with homologous mammalian serum albumins M Ishtikhar, E Ahmad, Z Siddiqui, S Ahmad, MV Khan, M Zaman, S Nusrat, International journal of biological macromolecules 107, 2450-2464
  • Cysteine as a potential anti-amyloidogenic agent with protective ability against amyloid induced cytotoxicity M Zaman, SM Zakariya, S Nusrat, TI Chandel, SM Meeran, MR Ajmal, International journal of biological macromolecules 105, 556-565
  • Probing the interaction of cephalosporin antibiotic–ceftazidime with human serum albumin: A biophysical investigation MK Siddiqi, P Alam, SK Chaturvedi, S Nusrat, MR Ajmal, International journal of biological macromolecules 105, 292-299
  • Elucidating the interaction of clofazimine with bovine liver catalase a comprehensive spectroscopic and molecular docking approach M Zaman, S Nusrat, SM Zakariya, MV Khan, MR Ajmal, RH Khan Journal of Molecular Recognition 30 (8), e2619
  • Biophysical insights into the interaction of hen egg white lysozyme with therapeutic dye clofazimine: modulation of activity and SDS induced aggregation of model protein MR Ajmal, SK Chaturvedi, N Zaidi, P Alam, M Zaman, MK Siddiqi, Journal of Biomolecular Structure and Dynamics 35 (10), 2197-2210
  • Anti-parkinsonian l-dopa can also act as anti-systemic amyloidosis—A mechanistic exploration S Nusrat, N Zaidi, MK Siddiqi, M Zaman, IA Siddique, MR Ajmal, International journal of biological macromolecules 99, 630-640
  • A biophysical and computational study unraveling the molecular interaction mechanism of a new Janus kinase inhibitor Tofacitinib with bovine serum albumin AS Abdelhameed, S Nusrat, MR Ajmal, SM Zakariya, M Zaman, RH Khan Journal of Molecular Recognition 30 (6), e2601
  • Surfactant-mediated amyloidogenesis behavior of stem bromelain a biophysical insight M Zaman, SM Zakariya, S Nusrat, MV Khan, A Qadeer, MR Ajmal, Journal of Biomolecular Structure and Dynamics 35 (7), 1407-1419
  • Ascorbic acid inhibits human insulin aggregation and protects against amyloid induced cytotoxicity P Alam, AZ Beg, MK Siddiqi, SK Chaturvedi, RK Rajpoot, MR Ajmal, Archives of biochemistry and biophysics 621, 54-62
  • Interaction of anticancer drug clofarabine with human serum albumin and human α-1 acid glycoprotein Spectroscopic and molecular docking approach MR Ajmal, S Nusrat, P Alam, N Zaidi, MV Khan, M Zaman, YE Shahein, Journal of Pharmaceutical and Biomedical Analysis 135, 106-115
  • Insight into the Interaction of antitubercular and anticancer compound Clofazimine with Human Serum Albumin: spectroscopy and molecular modelling MR Ajmal, N Zaidi, P Alam, S Nusrat, MK Siddiqi, G Badr, MH Mahmoud, Journal of Biomolecular Structure and Dynamics 35 (1), 46-57
  • Fibrillogenesis of human serum albumin in the presence of levodopa–spectroscopic, calorimetric and microscopic studies MR Ajmal, TI Chandel, P Alam, N Zaidi, M Zaman, S Nusrat, MV Khan, International journal of biological macromolecules 94, 301-308
  • Repositioning nordihydroguaiaretic acid as a potent inhibitor of systemic amyloidosis and associated cellular toxicity S Nusrat, N Zaidi, M Zaman, S Islam, MR Ajmal, MK Siddiqi, MK Santra, Archives of Biochemistry and Biophysics 612, 78-90
  • Correction: A Comprehensive Spectroscopic and Computational Investigation to Probe the Interaction of Antineoplastic Drug Nordihydroguaiaretic Acid with Serum Albumins S Nusrat, MK Siddiqi, M Zaman, N Zaidi, MR Ajmal, P Alam, A Qadeer, Plos one 11 (10), e0164927
  • In vitro elucidation of the folding intermediates and aggregate formation of hemoglobin induced by acetonitrile: a multispectroscopic approach M Furkan, A Rizvi, M Afsar, M Rehan Ajmal, R H Khan, A Naeem Protein and Peptide Letters 23 (10), 884-891
  • Differential mode of interaction of ThioflavinT with native β structural motif in human α 1-acid glycoprotein and cross beta sheet of its amyloid: Biophysical and molecular … MR Ajmal, S Nusrat, P Alam, N Zaidi, G Badr, MH Mahmoud, RK Rajpoot, Journal of molecular structure 1117, 208-217
  • A comprehensive spectroscopic and computational investigation to probe the interaction of antineoplastic drug nordihydroguaiaretic acid with serum albumins S Nusrat, MK Siddiqi, M Zaman, N Zaidi, MR Ajmal, P Alam, A Qadeer, PLoS One 11 (7), e0158833
  • Interaction of the recently approved anticancer drug nintedanib with human acute phase reactant α 1-acid glycoprotein AS Abdelhameed, MR Ajmal, K Ponnusamy, N Subbarao, RH Khan Journal of Molecular Structure 1115, 171-179
  • Vitamin k3 inhibits protein aggregation: implication in the treatment of amyloid diseases P Alam, SK Chaturvedi, MK Siddiqi, RK Rajpoot, MR Ajmal, M Zaman, Scientific reports 6 (1), 26759
  • Interaction of new kinase inhibitors cabozantinib and tofacitinib with human serum alpha-1 acid glycoprotein A comprehensive spectroscopic and molecular Docking approach MR Ajmal, AS Abdelhameed, P Alam, RH Khan Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 159, 199-208
  • Differential mode of interaction of ThioflavinT with native b structural motif in human a amyloid: Biophysical and molecular docking approach MR Ajmal, S Nusrat, P Alam, N Zaidi, G Badr, MH Mahmoud, RK Rajpoot, Journal of Molecular Structure 1117, 208e217
  • Biophysical and molecular docking insight into the interaction of cytosine β-D arabinofuranoside with human serum albumin P Alam, SK Chaturvedi, T Anwar, MK Siddiqi, MR Ajmal, G Badr, Journal of Luminescence 164, 123-130
  • Secondary structural changes in guanidinium hydrochloride denatured mammalian serum albumins and protective effect of small amounts of cationic gemini surfactant pentanediyl-α … N Gull, JM Khan, M Ishtikhar, A Qadeer, RA Khan, M Gul, RH Khan Journal of colloid and interface science 439, 170-176
  • A comprehensive insight into binding of hippuric acid to human serum albumin: a study to uncover its impaired elimination through hemodialysis N Zaidi, MR Ajmal, G Rabbani, E Ahmad, RH Khan PloS one 8 (8), e71422
  • Biophysical insight into furosemide binding to human serum albumin: a study to unveil its impaired albumin binding in uremia N Zaidi, E Ahmad, M Rehan, G Rabbani, MR Ajmal, Y Zaidi, N Subbarao, The Journal of Physical Chemistry B 117 (9), 2595-2604
جوائز التميز
  • University Grants Commission and council for scientific and industrial research fellowship, government of India
  • Department of Biotechnology, Government of India, doctoral research fellowship award
  • University Grants Commission, National Eligibility Test Qualified
المشاريع البحثية
اسم المشروع وصف المشروع
preservation of protein structure using co solvents Human blood serum protein albumin (HSA) is well studied protein owing its importance being a carrier molecule for endogenous molecules, toxins, xenobiotics and other small ligands like metal ions The structure of protein is related to its function and perturbations in structure reflect in function In the present study we studied the interaction of heavy metal ion cobalt with human serum albumin Present study reports spectroscopic studies in presence of cobalt ion alone and in presence of cosolvent Here, we elucidated the interaction of cobalt with HSA and role of glycerol as auxiliary solvent in this process is evaluated Cobalt interaction with human serum albumin causes the aggregation of protein as indicated by fluorescence emission increase, thioflavin-T (Th-T) binding and scattering data also support the denaturation of protein phenomenon in presence of cobalt This study evaluated the role of glycerol in denaturation of HSA in presence of cobalt, It was observed that HSA incubated when incubate with glycerol was protected against cobalt induced denaturation as indicated by loss of ThT fluorescence Glycerol is postulated to be an important auxiliary solvent in protection of protein from heavy metal induced aggregation Heavy metals are present in environment and interaction with humans is inevitable also metal ions in protein formulations can cause protein denaturation Prevention from exposure to cobalt is important as interaction with proteins can cause them lose function due to denaturation and aggregation causing diseases and toxicity
application of date palm biowaste in micropollutant removal from contaminated water The conventional waste management practices generally goal to dispose biological waste from farms and forest Many times these strategies, contribute to the environmental pollution like incineration and at the same time biomass is lost This biowaste has a great potential of reuse so innovative thinking in this direction is desired In present research date palm biowaste is applied to look for removal of diphenylamine from contaminated water samples Date seed powder was applied to look into the removal of diphenylamine from contaminated water, ultraviolet visible spectroscopy results indicated decreased diphenylamine absorbance in date palm biowaste samples indicating sequestration of chemical pollutant from water Our research suggested the possible application of date palm biowaste in micropollutant removal from contaminated water Further research is needed in this direction to have full understanding of this phenomenon and to optimise this process so that it can be applied and executed at large scale The application bio-waste produced by farming activities when applied as adsorbent for wastewater treatment, it can tackles water contamination, decreases the overall amount of agricultural waste, and reduces the potential gas emissions caused by waste transportation, treatment and disposal
معلومات التواصل
البريد الإلكتروني : mkhan@UT.EDU.SA
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