الصفحة الرئيسية

كلية العلوم \ الكيمياء

سعيد مختار عبدالحكيم نورمحمد

السيرة الذاتية
نسبة اكتمال الملف الشخصي
الجنسية الهندية
التخصص العام كيمياء
التخصص الدقيق كيمياءعضوية
المسمى الوظيفي أستاذ مساعد
الدرجة العلمية (المرتبة) دكتوراه

نبذه مختصرة

Dr Sayeed Mukhtar is working as associate professor in the department of chemistry faculty of science university of Tabuk He is having More than nineteen years of post doctoral experience in teaching and scientific research He is having 30 scientific papers published in journals of international repute and having US patent in Process for the Preparation of Cinacalcet

المؤهلات العلمية

PhD in Organic Chemistry MSc in Organic Chemistry

الاهتمامات البحثية

Design and Synthesis of biologically active compounds containing S and N heterocycles 1 Designed and synthesized biologically active heterocyclic compounds such as thiazolidin-4-one, Pyrazoline, Pyrimidine, imidazole and chromene derivatives 1 Synthesis of biologically active heterocyclic compounds such as novel sulphur and nitrogen containing ferrocenyl linked heterocyclic compounds, novel 6-ferrocenyl-4-aryl-2-substituted pyrimidines, novel pyrimidine‐based ferrocenyl substituted organometallic compounds, novel pyrazoline‐based organometallic compounds, Organometallic macromolecules such as ferrocenyl bis-pyrazoline and bis-pyrimidine derivatives, 2,4,6 trisubstituted bis-pyrimidines, bis-dioxazoles, carbamates, thiosemicarbazones and hydroxy pyrazolines, tetrazoles, and fatty acid derivatives 2 Developed three non infringing Processes (Routes) to prepare Cinacalcet HCl (API) chemically designated as N-[l-(R)-(-)-(l-naphthyl)ethyl]-3-[3-(trifluoromethyl)phenyl]-l-aminopropane hydrochloride The Drug Cinacalcet HCl is used for the treatment of secondary hyper parathyroidism in patients with chronic kidney disease on dialysis and for the treatment of hypercalcemia in patients with parathyroid carcinoma

الخبرات والمناصب الإدارية

More than nineteen years of experience in teaching and scientific research 2 Associate Professor in the Department of chemistry, Faculty of Science: 20th September 2021 -Till date 3 Assistant Professor in the Department of chemistry, Faculty of Science: 01/2011 – 19th September 2021 2 Ranbaxy Labs Ltd, Gurgaon, India, Senior Research Scientist: 12/2005 – 12/2010

الجدول الدراسي
اليوم المادة الوقت
من إلى
الأحد Organic Chemistry-2 08:00 10:00
الأحد Organic Chemistry-1 12:00 14:00
الأحد Chemistry of petroleum and petrochemicals 14:00 16:00
الإثنين General Chemistry-2 08:00 10:00
الثلاثاء Inorganic Chemistry-1 08:00 09:30
الثلاثاء [Practical]Spectroscopy of organic compounds 10:00 12:00
الثلاثاء Management of hazardous and non-hazardous solid wastes 14:00 16:00
الخميس Inorganic Chemistry-1 08:00 09:30
الخميس Organic Chemistry-2 10:00 12:00
الأبحاث والمؤلفات
  • 1 Nur Farisya Shamsudin, Qamar Uddin Ahmed,*, Syed Mahmood , Syed Adnan Ali Shah, Alfi Khatib, Sayeed Mukhtar, Meshari A Alsharif, Humaira Parveen and Zainul Amiruddin Zakaria “Antibacterial Effects of Flavonoids and Their Structure-Activity Relationship Study: A Comparative Interpretation Molecules, 27, 2022, 1149, (Impact factor 3267, Q2), Published by MDPI [Multidisciplinary Digital publishing Institute, Switzerland] https://doiorg/103390/molecules270411491
  • 2 Mohammed Issa Alahmdi, Mahmoud A Abdelaziz Mahmoud, Rafat M Mohareb, Sayeed Mukhtar, Syed Khasim, Meshari A Alsharif, Yasser A Selim,⃰ Nahla S Zidan “Green Synthesis of Copper and Palladium Nanoparticles Using Heterocyclic Polyphenolic of Leaves of Eruca sativa and it’s In vitro Anticancer Activity Wulfenia Journal, Vol 28 (12), 2021, 58-70 (impact Factor 0941 , Q3) ISSN: 1561-882X
  • 3 Salman A Khan, Qasimullah, Humaira Parveen, Sayeed Mukhtar, Khalid Ahmed Alzahrani, Mohammed Asad, “Synthesis and Photophysical investigation of novel an Imidazole derivative an Efficient multimodal chemosensor for Cu (II) and Fluoride ions, Journal of Photochemistry and Photobiology A: Chemistry, 406, 2021, 113022 (impact factor 3306, ISI Journal, Q2), Published by Elsevier https://doiorg/101016/jjphotochem2020113022
  • 4 Qamar Uddin Ahmed, Abdul Hasib Mohd Ali, Sayeed Mukhtar, Meshari A Alsharif, Humaira Parveen, Mohamed Sufian Mohd Nawi, Alfi Khatib, Jamshed Siddiqui, Awis Sukarni Mohmad Sabere, Abdulrashid Umar, Alhassan Muhammad Alhassan, “Medicinal Potential of Isoflavonoids: Polyphenols that May Cure Diabetes Molecules, 25, 2020, 5491, (Impact factor 3267, Q2), Published by MDPI [Multidisciplinary Digital publishing Institute, Switzerland] doi:103390/molecules25235491
  • 5 Meshari A Alsharif, Danish Khan, Naseem Ahmed, Sayeed Mukhtar, Parvez Khan, Md Imtaiyaz Hassan, Abdulraheem S A Almalki, and Rami J Obaid, " Pharmacological Activities of Novel Chromene Derivatives as Calcium/Calmodulin Dependent Protein Kinase IV (CAMKIV) Inhibitors", Chemistry Select, 2020, 5, 498–505 (impact factor 1811, ISI Journal, Q2)
  • 6 Danish Khan, Naseem Ahmed, Meshari A Alsharif, Mohammed Issa Alahmdi, and Sayeed Mukhtar, "SeO2 Mediated Synthesis of Selected Heterocycles by Oxidative C-C Bond Cleavage of Acetophenone Derivatives" ChemistrySelect, 2019, 4,7585–7590 (impact factor 1811, ISI Journal, Q2)
  • 7 Mohd Waheed, Naseem Ahmed, Meshari A Alsharif, Mohammed Issa Alahmdi, and Sayeed Mukhtar, " K2S2O8-Mediated Efficient Oxidative Deoximation of Flavonoid Oximes under Mild Reaction Conditions" ChemistrySelect, 2019, 4,7572–7576 (impact factor 1811, ISI Journal, Q2)
  • 8 Mohd Waheed, Naseem Ahmed, Meshari A Alsharif, Mohammed Issa Alahmdi, and Sayeed Mukhtar, “PhI(OAc)2-Mediated One-Pot Synthesis and their Antibacterial Activity of Flavone and Coumarin Based Isoxazoles Under Mild Reaction Conditions Chemistry Select 4 (2019) 1872–1878 (impact factor 1811, ISI Journal, Q2)
  • 9 Meshari A Alsharif, Danish Khan, Sayeed Mukhtar, Mohammed Issa Alahmdi, and Naseem Ahmed, KOtBu-Mediated Aza-Michael Addition of Aromatic Amines or N-Phenylurea to 3-Nitro-2-phenyl-2H-chromenes and Sequential Aerobic Dehydrogenation, Eur J Org Chem 2018(26) (2018) 3434-3463 (Impact factor: 2980, ISI Journal, Q1)
  • 10 Meshari A Alsharif, Sayeed Mukhtar, Abdullah M Asiri, Salman A Khan, “One pot synthesis, physicochemical and photophysical investigation of biologically active pyridine-3-carboxylate (ECPC) as probe to determine CMC of surfactants in organized media, Colloids and Surfaces A, 543 (2018) 38-45 (impact factor: 3990, ISI Journal, Q1)
  • 11 Mohd Waheed, Naseem Ahmed, Meshari A Alsharif, Mohammed Issa Alahmdi and Sayeed Mukhtar “One-Pot Synthesis of 1,5-Diketones from 3-acetyl-4- Hydroxycoumarin and Effective Cyclization to Unexpected 3, 4- Dihydropyridines’ Org Biomol Chem, 16 (2018) 3428 (impact factor: 3412, ISI Journal, Q1)
  • 12 Humaira Parveen, Raedah Aiyed Suliman Alatawi, Meshari A Alsharif, Mohammed Issa Alahmdi, Sayeed Mukhtar, Salman Ahmad Khan, Sadaf Hasan, Asad U Khan, “Novel Pyrazoline-based Organometallic Compounds Containing Ferrocenyl and Quinoline units: Synthesis, Characterization and Microbial susceptibilities Appl Organomet Chem, 32(4) (2018) e4257 (Impact factor: 2740, ISI Journal, Q2)
  • 13 Humaira Parveen, Meshari A Alsharif, MI Alahmdi, S Mukhtar, A Azam, “Novel pyrimidine-based ferrocenyl substituted organometallic compounds: Synthesis, characterization and Biological evaluation Applied Organometalic Chemistry, Appl Organomet Chem, 32(4) (2018) e4261 (Impact factor: 2740, ISI Journal, Q2)
  • 14 Sayeed Mukhtar, Meshari A Alsharif, Mohammed I Alahmdi, Humaira Parveen, “Synthesis, Characterization, Stereochemistry and Biological Evaluation of Novel Cyclohexanol Derivatives, Asian Journal of Chemistry, vol 30, No 5 (2018) 1102-1108 (impact factor 031, Q4 journal, indexed in Scopus)
  • 15 Mohammed Waheed, Naseem Ahmed, Meshari A Alsharif, Mohammed Issa Alahmdi and Sayeed Mukhtar “An Efficient Synthesis of 2,4,5-Trisubstituted and 1,2,4,5-Tetrasubstituted Imidazoles Using Dihydroquinolines as Novel Organocatalyst, Chemistry Select 2(26) (2017 )7946–7950 (impact factor 1811, ISI Journal, Q2)
  • 16 Danish Khan, Sayeed Mukhtar, Meshari A Alsharif, Mohammed Issa Alahmdi, Naseem Ahmed, “PhI(OAc)2 mediated an efficient Knoevenagel reaction and their synthetic application for coumarin derivatives, Tetrahedron Lett , 58 (2017) 3183–3187 (Impact factor 2379, ISI Journal, Q2)
  • 17 Humaira Parveen, Raedah Aiyed Suliman Alatawi, Nadia Hussein El Sayed, Sadaf Hasan, Sayeed Mukhtar, Asad U Khan, “Synthesis, characterization and biological evaluation of some novel nitrogen and sulphur containing organometallic heterocycles, Arabian Journal of Chemistry, vol 10 (8) (2017) 1098-1106 (impact factor: 3620, ISI Journal, Q2)
  • 19 Humaira Parveen, Sayeed Mukhtar, Amir Azam Novel Ferrocenyl Linked Pyrazoline Analogs as Potent Anti-amoebic Agents, Journal of heterocyclic chemistry, vol 53, (2), (2016), 473-478 (impact factor: 1484, ISI Journal, Q3)
  • 19 Humaira Parveen, Sayeed Mukhtar, Amir Azam Novel Ferrocenyl Linked Pyrazoline Analogs as Potent Anti-amoebic Agents, Journal of heterocyclic chemistry, vol 53, (2), (2016), 473-478 (impact factor: 1484, ISI Journal, Q3)
  • 20 Humaira Parveen, Raedah Aiyed Suliman Alatawi, Salman Ahmad Khan, Mohammed Issa Al-Ahmdi, Sayeed Mukhtar, Amir Azam and Nadia Hussein El Sayed, Synthesis, Characterization and Biological Evaluation of Novel 1-N-Substituted Thiocarbomoyl-3-Ferrocenyl-2- Pyrazoline Derivatives, Asian Journal of Chemistry Vol 28, No 8 (2016), 1835-1840 (impact factor 031, Q4 journal, indexed in Scopus)
  • 21 Sayeed Mukhtar , Waleed Atef Manasra , Humaira Parveen , Amir Azam, Synthesis Characterization, Antiamoebic activity and Toxicity of Ferrocenyl Chalcones, Asian Journal of Chemistry Vol 26, No 24 (2014), 8407-8412 (impact factor 031, Q4 journal, indexed in Scopus)
  • 22 Humaira Parveen, Sayeed Mukhtar, Nadia Hussein El Sayed, Faisal Hayat, Synthesis, characterization and antimicrobial activity of long chain fatty alkenoates of metronidazole and their novel tetrazole derivatives, Asian Journal of Chemistry Vol 26, No 23 (2014), 8134-8138 (impact factor 031, Q4 journal, indexed in Scopus)
  • 23 Humaira Parveen, Faisal Hayat, Sayeed Mukhtar, Attar Salahuddin, Andleeb Khan, Fakhrul Islam, Amir Azam, Synthesis, characterization and biological evaluation of novel 2,4,6-trisubstituted bis-pyrimidine derivatives, European Journal of Medicinal Chemistry, 46, 2011, 4669-4675 (impact factor: 5572, ISI Journal, Q1)
  • 24 VP Mujeebur Rahman, Sayeed Mukhtar, Wajid Husain Ansari*, Guy Lemiere, Synthesis, stereochemistry and biological activity of some novel long alkyl chain substituted thiazolidin-4-ones and thiazan-4-one from 10-undecenoic acid hydrazide European Journal of Medicinal Chemistry, 40, 173 (2005) (impact factor: 5572, ISI Journal, Q1)
  • 25 Sayeed Mukhtar, Mujeebur Rahman VP, Wajid Huasain Ansari*, Guy Lemiere, Alex De Groot and Roger Dommisse, Bifunctional Derivatives of p,p-Dichlorochalcone Part II Synthesis of a novel compound 2-[2-(carboxymethylthio-2-(4-chlorophenyl)ethyl]-2-(4-chlorophenyl)-4-thiazolidinone, molecules, 4 (1999) 232 (impact factor: 3267, ISI Journal, Q2)
  • 26 Mohammed Issa Alahmdi, Syed Khasim, Sekar Vanaraj, Chellasamy Panneerselvam, Mahmoud A Abdelaziz Mahmoud, Sayeed Mukhtar, Meshari A Alsharif, Nahla S Zidan, Nader Elmaghwry Abo Dya, Obaid F Aldosari, “Green Nanoarchitectonics of ZnO Nanoparticles from Clitoria ternatea Flower Extract for In Vitro Anticancer and Antibacterial Activity: Inhibits MCF 7 Cell Proliferation via Intrinsic Apoptotic Pathway Journal of Inorganic and Organometallic Polymers and Materials, Published online on 14 March 2022 (Impact factor 3543, Q2), Published by Springer) https://doiorg/101007/s10904-022-02263-7
  • 27 Abdulrashid Umar, Hassan M Faidallah, Qamar Uddin Ahmed, KhalidA Alamry, Sayeed Mukhtar, Meshari A Alsharif, Syed Najmul Hejaz Azmi, Humaira Parveen, Zainul Amiruddin Zakaria, Mostafa A Hussien, “Design, synthesis, in vitro antiproliferative effect and in situ molecular docking studies of a series of new benzoquinoline derivatives, Journal of King Saud University-Science, 34, (4), 2022, 102003, (Impact Factor 4011, Q1), published by Elsevier https://doiorg/101016/jjksus2022102003
  • 28 Meshari A Alsharif, Naseem Ahmed, Mohammed Issa Alahmdi, Sayeed Mukhtar, Humaira Parveen, Rami J Obaid, Abdulraheem SA Almalki, “Divergent synthesis of fused Benzo-xanthene and oxazine derivatives via Cu-catalyst J Saudi Chem Soc 26, 2022, 101568 https://doiorg/101016/jjscs2022101568
  • 29 Mohd Waheed, Meshari A Alsharif, Mohammed Issa Alahmdi, Sayeed Mukhtar, Humaira Parveen, “Visible light mediated Iron-Catalyzed synthesis of C-3 alkylated Indoles, bisindolylmethanes and flavanones using alcohols Tetrahedron Letters, Available online 3 March 2023, 154428, Article in Press https://doiorg/101016/jtetlet2023154428
  • 30 MOHD WAHEED, Meshari A Alsharif, Mohammed Issa Alahmdi, Sayeed Mukhtar, Humaira Parveen, “Visible Light Promoted Iron-Catalyzed One-Pot Synthesis of 2-Arylimino-2H-Chromenes from 2-Hydroxybenzyl Alcohols and β-Ketothioamides at Room Temperature First published on 06 March 2023, Article in Press https://doiorg/101002/ejoc202300136
جوائز التميز
  • Nothing
المشاريع البحثية
اسم المشروع وصف المشروع
Design, Synthesis, molecular modelling studies and Anti-proliferative activity of Phenothiazine based novel compounds The development of synthetic strategies facilitating the building of useful molecular architectures with biological potential as anti-The development of synthetic strategies facilitating the building of useful molecular architectures with biological potential as anti-cancer activities is highly demanding and equally challenging to academia and industries Due to this reason, it is imperative to design and develop new anti-proliferative agents having novel chemical entities for example, heterocyclic cores preferably with different mode of actions rather than analogues of the existing ones In this research proposal, our aim is to study an efficient method for the synthesis, and spectroscopic, molecular docking and anti-proliferation studies of phenothiazine derivatives against Human cancer cell lines Compounds will be synthesized using phenothiazine based chalcones and 2-aminopyridine derivatives Some derivatives will be obtained directly from commercial available or synthesized with the literature reported procedures These compounds will be evaluated in in vitro studies for the binding assay, kinase assay, cytotoxicity, apoptosis, etc against human breast cancer cell lines Furthermore, the molecular docking study and the structure-activity relationship (SAR) analysis will performed with active compounds against MARK4 protein
One pot synthesis, spectroscopic and photophysical studies of biologically active pyridine-3-carboxylate derivatives In this research project our aim is to study the one pot synthesis, spectroscopic and photophysical properties of biologically active pyridine-3-carboxylate derivatives Pyridine-3-carboxylate will be synthesis by the one pot multi component reaction of indane-1,3-dione with corresponding aldehyde and ethyl acetoacetate The structure of the novel pyridine-3-carboxylate derivatives will be characterized by spectroscopy technique including FT-IR, H, C-NMR spectroscopy The electronic absorption and emission spectra of novel molecules will be studied in different media Physicochemical studies such as singlet absorption, emission, molar absorptivity, di-electric constant and fluorescence quantum yield of newly synthesized novel pyridine-3-carboxylate derivative will also determined Antibacterial activity of these novel pyridine-3-carboxylate derivative will evaluated by the disk diffusion and micro dilution methods against Gram-positive and Gram-negative bacteria
Synthesis, characterization and anticancer studies of flavanoidal derivatives containing thiazolidinone moiety to develop potent anticancer agents Cancer is a growing health problem around the world and is the second leading cause of death after heart disease Current estimates from the American Cancer Society and from the International Union against Cancer indicate that 12 million cases of cancer were diagnosed last year, with 7 million deaths worldwide these numbers are expected to double by 2030[1]Chemotherapy is an important option in modern cancer treatment and many anticancer drugs are currently used for treatment of cancer but resistance to multiple chemotherapeutic agents is common and still unsolved clinical problem in the treatment of cancerThe identification of new experimental strategies involving novel agents or drugs capable of killing resistant cells is, therefore, of utmost interest in cancer research [2] Flavonoids and thiazolidinone derivative have been found to be associated with diverse biological activities [3-9] and are promising agents for treating most dangerous diseases like cancer [10], AIDS [11-13] and hepatitis B [14] Also, flavonoids are naturally occurring antioxidant and have been implicated as novel antiviral and antitumor compounds [15] Literature survey has revealed that there are no reports for the synthesis of flavanoidal thiazolidinones In view of these findings, the aim of this research project is to discover potent anticancer agents with less toxicity, which includes the synthesis of some novel flavanoidal-spiro-thiaolidin-4-ones derivatives and their anticancer activities
Synthesis and biological studies of new quinoline derivatives containing pyrazoline moiety to develop potent antibacterial and anti-tubercular agents Tuberculosis (TB) is an infectious disease caused by different species of mycobacteria Around 2 million people throughout the world die annually from tuberculosis and there are around 9 million new cases each year[1]As a result, it has become a major public health problem in most of the developing countries Every year about 02 million people living with HIV/AIDS die from TB [2]Furthermore, in recent times the appearance of multidrug-resistant TB(MDR-TB),a form of TB that does not respond to the first-line TB drugs, has become a serious threat to TB control and its treatment All the above facts reveal that there is an urgent need for development of new drugs with divergent and unique structure and with a mechanism of action possibly different from that of existing drugs Among the important heterocyclic moieties of biological and pharmacological interest, the quinoline ring is endowed with various activities such as antituberculosis [3], antimalarial [4], anti- inflammatory [5], anticancer [6], antibiotic [7], antihypertensive [8], tyro kinase PDGF-RTK inhibiting agents [9], anti HIV [10,11] and with possibly a new mantibacterial as well as antituberculosis activities [12-15] The aim of this research project is to develop quinoline derivatives containing pyrazoline moiety as therapeutic agents for tuberculosis ode of action
Design, synthesis and biological studies of ferrocenyl chalcone derivatives to develop potent antiamoebic agents Amoebiasis (amoebic dysentery) is the most aggressive protozoal disease and considered to be the second or third leading cause of death amongst the parasitic diseases [1] Entamoeba histolytica, a protozoan parasite, is the causative agent of amoebiasis, which is more prevalent in tropical and subtropical regions [2] and also in Saudi Arabia Metronidazole is known to be highly effective amoebicide and is considered to be the drug of choice for the treatment of amoebiasis, but it has been shown to be mutagenic in a microbiological system and carcinogenic to rodents [3–5] Repeated treatment of Entamoeba histolytica infection with commonly used antiamoebic drugs results in not only increasing the toxicity potential but also leads to the development of clinical resistance Therefore, new effective agents with less toxicity against amoebiasis are urgently required The integration of ferrocene units into a heterocyclic molecule has long been recognized as an attractive way to endow novel molecule functionality [6] Many ferrocenyl-substituted compounds display interesting cytotoxic, anti-tumor, antimalarial, antifungal, DNA-cleaving activity [7-9] and as potential pharmaceuticals [10-15] Moreover, the stability and non toxicity of the ferrocenyl moiety is of particular interest rendering such drugs compatible with other treatment [16] The aim of this research project is to discover and develop better and yet safer therapeutic agents for amoebiasis (Amoebic dysentery)
معلومات التواصل
البريد الإلكتروني : snoor@ut.edu.sa
2640

الخصوصية وملفات تعريف الارتباط
هذا الموقع يستخدم ملفات تعريف الارتباط الخاصة للتأكد من سهولة الاستخدام وضمان تحسين تجربتك أثناء التصفح. من خلال الاستمرار في تصفح هذا الموقع، فإنك تقر بقبول استخدامنا لملفات تعريف الارتباط. الشروط والأحكام.