الصفحة الرئيسية

كلية العلوم \ الكيمياء

هوميرا بارفين اثارنابي

السيرة الذاتية
نسبة اكتمال الملف الشخصي
الجنسية الهندية
التخصص العام الكيمياء
التخصص الدقيق كيمياء عضوية
المسمى الوظيفي أستاذ مشارك
الدرجة العلمية (المرتبة) دكتوراه

نبذه مختصرة

Dr Humaira Parveen is presently working as an associate professor in the department of chemistry, faculty of science, university of Tabuk, Saudi Arabia She has completed her PhD degree from Aligarh Muslim University, India in 2005 She has worked as Research Associate [from 2005-2008] and as project scientist [2008-2010] in the department of Chemistry, Jamia Millia Islamia-New Delhi, India She has more than 18 years of experience in teaching as well as in scientific research She has published 65 research papers in the journal of international repute and she is also serving as a reviewer of a number of international journals She has successfully completed seven research projects awarded by the Deanship of scientific research [DSR] from the University of Tabuk and one from the department of science and technology [DST]-government of India as principal investigator She has 1080 citations and a 17 h-index on Google scholar Her research interest includes- Synthesis of biologically active heterocyclic compounds such as novel sulphur and nitrogen containing ferrocenyl linked heterocyclic compounds, novel 6-ferrocenyl-4-aryl-2-substituted pyrimidines, novel pyrimidine and pyrazoline‐based ferrocenyl substituted organometallic compounds, Organometallic macromolecules such as ferrocenyl bis-pyrazoline and bis-pyrimidine derivatives, 2,4,6 trisubstituted bis-pyrimidines, bis-dioxazoles, carbamates, thiosemicarbazones and hydroxy pyrazolines, tetrazoles, and fatty acid derivatives

المؤهلات العلمية

PhD in Chemistry [Specialization is organic chemistry] MSc in Organic Chemistry BSc in Chemistry

الاهتمامات البحثية

1 Synthesis of biologically active heterocyclic compounds such as novel sulphur and nitrogen containing ferrocenyl linked heterocyclic compounds, novel 6-ferrocenyl-4-aryl-2-substituted pyrimidines, novel pyrimidine‐based ferrocenyl substituted organometallic compounds, novel pyrazoline‐based organometallic compounds, Organometallic macromolecules such as ferrocenyl bis-pyrazoline and bis-pyrimidine derivatives, 2,4,6 trisubstituted bis-pyrimidines, bis-dioxazoles, carbamates, thiosemicarbazones and hydroxy pyrazolines, tetrazoles, and fatty acid derivatives 2 Isolation, characterization and derivatization of naturally occurring compounds from Medicinal Plants 3 In vitro quantitative estimation of synthesized and isolated compounds against Entameoba histolytica 4 The toxicological studies of synthesized and isolated compounds We have published a good number of papers in journals of international repute Many of the compounds tested were better inhibitor of E histolytica than the standard drug metronidazole Member of committee of question bank 2022 to till date

الخبرات والمناصب الإدارية

More than 18 years experience in teaching as well as in scientific research at University level Actively involve in teaching Graduate and post graduate courses Associate Professor in the Department of Chemistry, faculty of Science, University of Tabuk since 2021-till date Assistant Professor in the department of Chemistry, faculty of science, University of Tabuk from 2011-2021 Research Scientist in the Department of chemistry, Faculty of natural sciences, Jamia Millia Islamia (A central University), New Delhi-India from 2008-2010 Research Associate in the department of chemistry, faculty of Natural sciences, Jamia millia Islamia, New Delhi-India from 2005-2010 Member of different departmental committees such as Lab and Scientific research committees, Quality and Accreditation committees, Measurement and development committees etc Member of committee of program accreditation in the department of chemistry since 2022-till date Coordinator of committee for standardized tests in the department of chemistry 2022-till date Member of academic affairs committee in the department of chemistry [لجنة خريجين] Member of Alumni committee of the department of chemistry since 2022 till date Member of Quality and accreditation committee since 2020 to till date Member of Lab and Scientific research committee since 2020 to till date Member of Committee to discuss a decision on special issues in waste 2022 to till date) لجنة مناقشة مقرر موضوعات خاصة في ادارة المخلفات ) Member of Committee for preparing Intermediate diploma program from 2022 to till date ) لجنة اعداد برنامج الدبلوم المتوسط في ادارة المخلفات) Coordinator of Fundamental Chemistry [CHEM 1101] program in female section in the department of Chemistry

الجدول الدراسي
اليوم المادة الوقت
من إلى
الأحد Fundamentals of Biochemistry 12:00 14:00
الثلاثاء Enzymology 10:00 12:00
الثلاثاء Fundamentals of Biochemistry 12:00 14:00
الأربعاء Chemistry of Cement 08:00 10:00
الخميس Molecular Biology 08:00 10:00
الخميس Enzymology 12:00 14:00
الأبحاث والمؤلفات
  • Synthesis and Photophysical investigation of novel an Imidazole derivative an Efficient multimodal chemosensor for Cu (II) and Fluoride ions
  • Medicinal Potential of Isoflavonoids: Polyphenols that May Cure Diabetes
  • An in-vitro and in Silico Anticancer Study of FDA Approved Antidiabetic Drugs Glimepiride and Empagliflozin
  • Microwave-assisted Synthesis, Characterization, and Density Functional Theory Study of Biologically Active Ferrocenyl Bis-pyrazoline and Bis-pyrimidine as Organometallic Macromolecules
  • Novel Pyrazoline-based Organometallic Compounds Containing Ferrocenyl and Quinoline units: Synthesis, Characterization and Microbial susceptibilities
  • Novel pyrimidine- based ferrocenyl substituted organometallic compounds: Synthesis, characterization and Biological evaluation
  • Synthesis, Characterization, Stereochemistry and Biological Evaluation of Novel Cyclohexanol Derivatives
  • Synthesis, characterization and biological evaluation of some novel nitrogen and sulphur containing organometallic heterocycles
  • Optical properties of novel environmentally benign biologically active ferrocenyl substituted chromophores: A detailed insight via experimental and theoretical approach
  • Novel Ferrocenyl Linked Pyrazoline Analogs as Potent Antiamoebic Agents
  • Synthesis, Characterization and Biological Evaluation of Novel 1-N-Substituted Thiocarbomoyl-3-Ferrocenyl-2- Pyrazoline Derivatives
  • Synthesis, Stereochemistry and Antimicrobial activity of some Novel Flavanone-hydrazono-thiazolidin-4-ones from Flavanones
  • Synthesis, characterization and biological evaluation of novel pyrazoline analogue
  • In vitro susceptibility of Entamoeba histolytica to Fraxinus micrantha leaf extracts and its isolated constituents
  • Synthesis, Characterization and Antimicrobial Activity of Long Chain Fatty Alkenoates of Metronidazole and their Novel Tetrazole Derivatives
  • Synthesis, Characterization, Antiamoebic Activity and Toxicity of Ferrocenyl Chalcones
  • Synthesis, characterization and biological evaluation of novel 2,4,6-trisubstituted bis-pyrimidine derivatives
  • Synthesis, characterization, and biological evaluation of novel 6-ferrocenyl-4-aryl-2-substituted pyrimidine derivatives
  • Synthesis, characterization, antiamoebic activity and toxicity of novel bisdioxazole derivatives
  • Synthesis and characterization of a new series of Hydroxy Pyrazolines
  • (Z)-12-Hydroxyoctadec-9-enoic acid in Sesbania aculeata seed oil
  • Preparation, Characterization and Antimicrobial Activity of Fatty Alkenoates
  • Direct Esterification of Fatty Acids with Phenyl Alkanols by using Dicyclohexylcarbodiimide
  • Synthesis and Characterization of -Bromo 5-Methyl Tetrazoles from Long Chain Fatty Alkenoates
  • Triacylglycerols-Analysis of three Medicinal Seed Oils using Pancreatic Lipase
  • Triacylglycerols-Profiling by High Performance Liquid Chromatography for Detection of Lard in Palm Oil
  • Microwave assisted one-pot synthesis, photophysical and physicochemical studies of novel biologically active heterocyclic Donor (D)-π-Acceptor (A) chromophore
  • Antibacterial effects of flavonoids and their structure activity relationship study: A comparative interpretation
  • “Microwave assisted one-pot synthesis, photophysical and physicochemical studies of novel biologically active heterocyclic Donor (D)-π-Acceptor (A) chromophore
  • Antibacterial effects of flavonoids and their structure activity relationship study: A comparative interpretation
  • Design, synthesis, in vitro antiproliferative effect and in situ molecular docking studies of a series of new benzoquinoline derivatives
  • Anticancer activity of bioactive compounds of chavicolas potential toxic against human Lung Cancer A549 Cell
  • Biomimetic synthesis of Piper betle decorated nano copper oxide: Investigations of their antioxidant, antibacterial and apoptotic efficacy
  • Divergent Synthesis of Fused Benzo-xanthene and Oxazine derivatives via Cu-catalyst
  • Visible Light Mediated Iron-Catalyzed Synthesis of C-3 Alkylated Indoles, Bisindolylmethanes and Flavanones Using Alcohols
  • Visible Light promoted Iron-Catalyzed One Pot Synthesis of 2-Arylimino-2H-Chromenes From 2-Hydroxybenzyl Alcohols and β-Ketothioamides at Room Temperature
  • Microwave assisted one-pot synthesis, photophysical and physicochemical studies of novel biologically active heterocyclic Donor (D)-π-Acceptor (A) chromophore
  • Design, synthesis, in vitro antiproliferative effect and in situ molecular docking studies of a series of new benzoquinoline derivatives
  • Iron-catalyzed intramolecular reductive cyclization of o-nitroarenes to indoles under visible light irradiation
  • Ultrasound-assisted synthesis of chalcone: A highly sensitive and selective fluorescent chemosensor for the detection of Fe 3+ in aqueous media
  • Cytotoxic activities and morphological studies of thiophene, thiazole and pyridazine derivatives synthesized from Benzo [d] thiazole derivatives
  • Anti-obesity and antihyperlipidemic effects of Phaleria macrocarpa fruit liquid CO2 extract: in vitro, in silico and in vivo approaches
  • Ethanolic Extract of Polygonum minus Protects Differentiated Human Neuroblastoma Cells (SH-SY5Y) against H2O2-Induced Oxidative Stress
  • Anti-proliferative, morphological and molecular docking studies of new thiophene derivatives and their strategy in ionic liquids immobilized reactions
  • Anticancer and Hepatoprotective Role of Selenium Nanoparticles against Liver Carcinogen Acrylamide Induced Toxicity: In-vitro and In-vivo Studies: Protective effects of Selenium nanoparticles
  • PhIO mediated one-pot synthesis of pyrroloquinolinediones from ortho-carbonyl anilines and maleimides
  • Recent Advances in Carbon Nanotube Utilizations in Perovskite Solar Cells: A Review
جوائز التميز
  • , Research Associateship [Post doctoral fellowship] awarded by Department of science and technology, Government of India
  • Young Science [Project Scientist] awarded by Department of Science and Technology, Government of India
المشاريع البحثية
اسم المشروع وصف المشروع
Synthesis and biological studies of novel heterocyclic compounds to develop potent antibacterial and anti-tubercular agents Tuberculosis (TB) is an infectious disease caused by different species of mycobacteria Around 2 million people throughout the world die annually from tuberculosis and there are around 9 million new cases each year As a result, it has become a major public health problem in most of the developing countries Every year about 02 million people living with HIV/AIDS die from TBFurthermore, in recent times the appearance of multidrug-resistant TB(MDR-TB),a form of TB that does not respond to the first-line TB drugs, has become a serious threat to TB control and its treatment All the above facts reveal that there is an urgent need for development of new drugs with divergent and unique structure and with a mechanism of action possibly different from that of existing drugs Among the important heterocyclic moieties of biological and pharmacological interest, the quinoline ring is endowed with various activities such as antituberculosis ,antimalarial , anti- inflammatory, anticancer, antibiotic, antihypertensive, tyro kinase PDGF-RTK inhibiting agents, anti HIV and antibacterial as well as antituberculosis activities The aim of this research project is to develop quinoline derivatives containing pyrazoline moiety as therapeutic agents for tuberculosis with possibly a new mode of action
Synthesis and biological studies of pyrazoline derivatives to develop potent antiamoebic agents Amoebiasis (amoebic dysentery) is the most aggressive protozoal disease and considered to be the second or third leading cause of death amongst the parasitic diseases [1] Entamoeba histolytica, a protozoan parasite, is the causative agent of amoebiasis, which is more prevalent in tropical and subtropical regions [2] and also in Saudi Arabia Metronidazole is known to be highly effective amoebicide and is considered to be the drug of choice for the treatment of amoebiasis, but it has been shown to be mutagenic in a microbiological system and carcinogenic to rodents [3–5] Repeated treatment of Entamoeba histolytica infection with commonly used antiamoebic drugs results in not only increasing the toxicity potential but also leads to the development of clinical resistance Therefore, new effective agents with less toxicity against amoebiasis are urgently required The integration of ferrocene units into a heterocyclic molecule has long been recognized as an attractive way to endow novel molecule functionality [6] Many ferrocenyl-substituted compounds display interesting cytotoxic, anti-tumor, antimalarial, antifungal, DNA-cleaving activity [7-9] and as potential pharmaceuticals [10-15] Moreover, the stability and non toxicity of the ferrocenyl moiety is of particular interest rendering such drugs compatible with other treatment [16] The aim of this research project is to discover and develop better and yet safer therapeutic agents for amoebiasis (Amoebic dysentery)
Discovery and Development of Novel Small Molecule Inhibitors against (Polymicrobial biofilms using Green Chemistry Approaches We propose a sustainable and green synthesis method for developing novel small molecule inhibitors that can disrupt polymicrobial biofilms and have the potential to enter clinical trials This approach will use Click Chemistry to obtain small molecule inhibitors with different substituents and functionalities for lead optimization To determine the therapeutic efficacy the minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC) and minimum fungicidal concentration (MFC) will be determined they broth micro dilution methods following CLSI guidelines Furthermore, the effect on mono and poly biofilm formation will be analyzed in a 96 well microtiter plate by crystal Violet, XTT reduction assay and CFU counts following standard protocols The entire biofilm activity will be further validated by using confocal laser microscopy Additionally, the impact on membrane integrity of both the pathogens in a single and mixed conditions will be evaluated using fluorescence microscopy and other advanced techniques This study will result in the development of some lead molecules against polymicrobial biofilms for biomedical and environmental applications, and after safety assessments and clinical trials, could be marketed
معلومات التواصل
البريد الإلكتروني : h.nabi@UT.EDU.SA
7227

الخصوصية وملفات تعريف الارتباط
هذا الموقع يستخدم ملفات تعريف الارتباط الخاصة للتأكد من سهولة الاستخدام وضمان تحسين تجربتك أثناء التصفح. من خلال الاستمرار في تصفح هذا الموقع، فإنك تقر بقبول استخدامنا لملفات تعريف الارتباط. الشروط والأحكام.